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外阴白色病变(慢性外阴营养不良症)是外阴较常见的良性疾病。本文以病理组织学为基础,结合临床资料,对其临床表现、外阴切除术后果及癌变率进行讨论。材料及方法对我院1969年以来病理诊断为上述疾病的组织切片进行了复查。临床资料齐全,有随访结果者共167例,其中单纯外阴切除29例,局部活检138例。组织标本皆用石腊切片,常规H·E 染包。病理组织分型按1975年国际外阴疾病学会(ISSVD)制定的外阴营养不良症的病理组织学分型标准,本组分型如下:1.增生型营养不良:共123例,占73.7%。组织形态特点为上皮增生,角化过度,棘细胞层增厚,钉脚延长,真皮层有不同程度的慢性炎症。其中伴有非典型增生者7例,组织形态为部分上皮细胞核增大,染色质增多,底层细胞密集,细胞极性紊乱。
Vulvar white lesions (chronic vulvar dystrophy) is a more common vulvar vulva disease. This article based on histopathology, combined with clinical data on its clinical manifestations, the consequences of vulvar resection and cancer rates were discussed. Materials and Methods The histological sections of the above pathology diagnosed in our hospital since 1969 were reviewed. Complete clinical data, there are a total of 167 cases of follow-up results, including simple vulvar resection in 29 cases, 138 cases of local biopsy. Tissue specimens were paraffin sections, conventional H · E dyed bags. Pathological type According to the 1975 International Society of Vulvar Diseases (ISSVD) developed vulvar dystrophy histopathological criteria, the components are as follows: 1. Hyperplastic malnutrition: a total of 123 cases, accounting for 73.7%. Tissue morphological characteristics of epithelial hyperplasia, hyperkeratosis, thickening of the spine cell layer, nail foot extension, the dermis has varying degrees of chronic inflammation. Among them, there were 7 cases with atypical hyperplasia. The morphology of the epithelium was partly epithelial nucleus, increased chromatin, dense cells in the bottom and disorder of cell polarity.