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目的探讨CA242和生存素(survivin)蛋白在胃癌中的表达及意义。方法应用免疫组织化学技术检测120例胃癌、30例异型增生和20例正常胃黏膜组织中CA242和survivin蛋白表达,并结合肿瘤的病理学行为和临床随访资料分析。结果在胃癌组织中,CA242和survivin阳性率分别为79.2%和75.8%,均显著高于异型增生和正常胃黏膜组织(P<0.05)。CA242和survivin表达与胃癌浆膜浸润、淋巴结转移和患者预后密切相关(P<0.05)。结论CA242和survivin表达与胃癌发生、转移和患者生存期有关,检测CA242和survivin蛋白表达可作为预测胃癌患者预后的参考指标。
Objective To investigate the expression and significance of CA242 and survivin in gastric cancer. Methods The expressions of CA242 and survivin protein in 120 cases of gastric cancer, 30 cases of dysplasia and 20 cases of normal gastric mucosa were detected by immunohistochemistry. Combined with the pathological behavior and clinical follow-up data of the tumors, the expressions of CA242 and survivin were detected. Results The positive rates of CA242 and survivin in gastric cancer tissues were 79.2% and 75.8%, respectively, which were significantly higher than those in dysplasia and normal gastric mucosa (P <0.05). The expression of CA242 and survivin were closely related to the serosal invasion, lymph node metastasis and prognosis in gastric cancer (P <0.05). Conclusions The expression of CA242 and survivin is related to the occurrence and metastasis of gastric cancer and the survival of patients. Detecting the expression of CA242 and survivin protein may be used as a reference index to predict the prognosis of patients with gastric cancer.