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Valuable chiral N-Boc-β-benzyl-β-amino acid was concisely synthesized via construction of chiral NBoc-3-benzyl-5-oxoisoxazolidine through cross-metathesis/conjugate addition/oxidation.All of the starting materials for the synthesis of chiral N-Boc-β-benzyl-β-amino acid are cheap,and two-step short procedure make it easy for the rapid construction of various chiral β-arylmethyl-β-amino acids and important drugs,such as sitagliptin phosphate.
Valuable chiral N-Boc-β-benzyl-β-amino acid was concisely synthesized via construction of chiral NBoc-3-benzyl-5-oxoisoxazolidine through cross-metathesis / conjugate addition / oxidation. All of the starting materials for the synthesis of chiral N-Boc-β-benzyl-β-amino acids are cheap, and two-step short procedure make it easy for the rapid construction of various chiral β-arylmethyl-β-amino acids and important drugs, such as sitagliptin phosphate.