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应用抗表皮生长因子受体（ＥＧＦＲ）单克隆抗体及免疫组化ＡＢＣ法，对外阴鳞癌、外阴白色病变和不典型增生组织中ＥＧＦＲ的表达进行检测。并与胸腹壁、腿部正常皮肤及外阴癌旁正常组织进行对照。结果：外阴鳞癌和不典型增生的阳性率明显高于其它类型的外阴白色病变（Ｐ＜０．０５），这种不同的表达说明ＥＧＦＲ与鳞状上皮细胞的增生转化与鳞癌的发生有一定关系。
The expression of EGFR in vulvar squamous cell carcinoma, vulvar white lesions and atypical hyperplasia tissues was detected by monoclonal antibody against epidermal growth factor receptor (EGFR) and immunohistochemical ABC method. And with the abdominal wall, leg normal skin and normal tissue adjacent to cancer control. Results: The positive rates of vulvar squamous cell carcinoma and atypical hyperplasia were significantly higher than those of other types of vulvar white lesions (P <0.05). The different expressions of EGFR and squamous cell hyperplasia and squamous cell carcinoma A certain relationship.