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[目的]观察单唾液酸四己糖神经节苷脂钠穴位注射治疗婴儿中枢性协调障碍疗效。[方法]使用随机平行对照方法,将60例住院及门诊患者按病志号抽签法简单随机分为两组。综合康复治疗,包括运动疗法、关节松动训练、针灸、低频电疗、中药熏蒸等。对照组30例单唾液酸四己糖神经节苷脂钠注射液20mg+5%葡萄糖50m L,1次/d,静滴。治疗组30例穴位注射,单唾液酸四己糖神经节苷脂钠,神庭、百会、角孙两侧、脑户,4个穴位/次,快速刺入皮下,缓慢推入,回抽无血后注入药物,5mg/穴,1次/d。连续治疗10d为1疗程。观测临床症状、DQ评分、不良反应。连续治疗3疗程,疗程间隔2周,判定疗效。[结果]治疗组显效12例,有效16例,无效2例,总有效率93.33%。对照组显效4例,有效18例,无效8例,总有效率73.33%。治疗组疗效优于对照组(P<0.05)。DQ评分两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。[结论]单唾液酸四己糖神经节苷脂钠穴位注射治疗婴儿中枢性协调障碍疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of point injection of mono-sialic acid tetrahexose ganglioside sodium on central coordination disorder in infants. [Methods] Using randomized parallel control method, 60 cases of inpatients and outpatients were randomly divided into two groups randomly according to the method of lot drawing. Comprehensive rehabilitation treatment, including exercise therapy, joint loose training, acupuncture, low frequency electrotherapy, traditional Chinese medicine fumigation. Control group, 30 cases of monosialotetrahexosyl ganglioside sodium injection 20mg + 5% glucose 50m L, 1 times / d, intravenous infusion. Treatment group, 30 cases of acupoint injection, monosialotetrahexosyl ganglioside sodium, Shen Ting, Baihui, angle Sun on both sides of the brain, 4 points / times, quickly pierced into the skin, slowly push, pull back without Blood injection of drugs, 5mg / point, 1 / d. Continuous treatment of 10d for a course of treatment. Observation of clinical symptoms, DQ score, adverse reactions. Continuous treatment of 3 courses, treatment interval of 2 weeks to determine the efficacy. [Result] In the treatment group, 12 cases were markedly effective, 16 cases were effective and 2 cases were ineffective. The total effective rate was 93.33%. In the control group, 4 cases were markedly effective, 18 cases were effective, 8 cases were ineffective and the total effective rate was 73.33%. The treatment group was better than the control group (P <0.05). DQ score improved in both groups (P <0.01), the treatment group improved better than the control group (P <0.01). [Conclusion] The single sialic acid tetrahexose ganglioside sodium acupoint injection is effective in treatment of infant central coordination disorders without serious adverse reactions and is worth promoting.