【摘 要】
：
目的 探讨中国山东省沿海地区汉族男性群体的白细胞介素(IL)-1β-511位点的多态性是否与痛风的易感性有关.方法 采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)检测276例
【机 构】
：
青岛大学医学院附属医院痛风病临床医学中心,青岛大学医学院附属医院脊柱外科,济南市第六人民医院儿科
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目的 探讨中国山东省沿海地区汉族男性群体的白细胞介素(IL)-1β-511位点的多态性是否与痛风的易感性有关.方法 采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)检测276例痛风患者和268名健康对照者的IL-1β-511位点的基因多态性分布.统计学处理采用x2检验和t检验.结果 IL-1β启动子区-511位点CC、CT和TT基因型频率在痛风组与健康对照组相比差异无统计学意义(x2=3.251,P=0.197,df=2)；2组的等位基因频率C和T间差异也无统计学意义(x2=2.941,P=0.086,OR=1.232,95％CI=0.971～1.563).经x2检验,IL-1β基因-511C/T位点基因多态性与痛风病的危险因素无相关性.痛风组与健康对照组相比,具有较高的体质量指数(BMI)、血压水平、血尿酸、血糖、甘油三酯及胆固醇水平,差异有统计学意义(P＜001).结论 中国沿海地区汉族男性人群中IL-1β-511C/T基因多态性与痛风的易感性无关联性.
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