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目的探讨本地区儿童感染柯萨奇B组病毒(CoxB)主要血清型流行病学分布。方法采用ELISA方法,检测住院感染性疾病儿童血清CoxBIgM4142例,并对9例髋关节滑膜炎患儿髋关节腔液进行病毒分离培养,利用中和试验鉴定病毒型别。结果CoxBIgM阳性370例,总阳性检出率为8.9%,对其中85例阳性标本进行了CoxB16型血清分型检测,其中CoxB3占54.1%,CoxB4占30.6%,首次在9例髋关节腔液病毒分离CoxB3病毒1株,并被其患儿恢复期血清所中和,其CoxBIgG有4倍增高。结论CoxB3和CoxB4是本地区的主要感染型。
Objective To explore the epidemiological distribution of major CoxB genotypes in children infected with CoxB. Methods Serum CoxBIgM4142 cases were detected by ELISA in children with hospital-acquired infectious diseases, and 9 cases of hip joint synovitis were isolated and cultured in the virus. Neutralization test was used to identify the virus types. Results The positive rate of CoxBIgM was 370%. The positive rate of CoxBIgM was 8.9%. CoxB16 serotypes were detected in 85 of them. CoxB3 accounted for 54.1% and CoxB4 accounted for 30.6%. For the first time, 9 cases of HHV A strain of CoxB3 was isolated and neutralized by its convalescent sera with a 4-fold increase in CoxBIgG. Conclusion CoxB3 and CoxB4 are the predominant infections in this area.