作者按照USP方法测定了14个批号不同规格的氯丙嗪糖衣片的溶出速率、崩解时限、含量均匀度和渗透速率,试图观察药物的溶出特性与生产日期、崩解时限及含量均匀度之间的关系。实验结果表明,各批氯丙嗪片均符合USP崩解时限。但港出速率没有一批符合USP要求(30分钟内药物溶出应不少于80％)。A_(100)和B_(100)氯丙嗪片于1小时后溶出才接近完全。 14批样品已贮存5～36个月,大部分批号溶出速率较小,与生产日期无相关性。多数情况下药物溶出速率小是由于片剂崩解不完全或不崩解所致。但以上各批均符 According to the USP method, the dissolution rate, disintegration time, content uniformity and permeation rate of 14 tablets of different specifications of chlorpromazine coated tablets were determined in order to observe the dissolution characteristics and production date, disintegration time and content uniformity of the drug Relationship between. The experimental results show that each batch of chlorpromazine tablets are in line with USP disintegration time limit. However, none of the rates in Hong Kong met the USP requirement (drug dissolution should be at least 80% within 30 minutes). The dissolution of A_ (100) and B_ (100) chlorpromazine tablets was almost complete after 1 hour. 14 batches of samples have been stored for 5 to 36 months, most of the lot number dissolution rate is small, no correlation with the production date. In most cases, small drug dissolution rates are due to incomplete or non-disintegration of the tablet. However, each of the above batches