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目的:检测支气管哮喘与病毒相关性喘息患儿血清Eotaxin和sICAM-1浓度,研究其与喘息反复发作高危因素之间的关系。方法:按中华儿科学会呼吸学组制定的统一标准随机选择支气管哮喘组和病毒相关性喘息组各60例,支气管哮喘组于急性发作期、慢性持续期采取血清,病毒相关性喘息组于急性期、恢复期采取血清,用酶联免疫吸附试验检测血清Eotax-in和sICAM-1浓度。对60例病毒相关性喘息患儿依据病史并进行1年随访,分析各组血清Eotaxin和sICAM-1浓度与喘息高危因素发生的关系。结果:病毒相关性喘息组急性期血清Eotaxin、sICAM-1浓度高于恢复期(P<0.01);喘息Ⅰ组(喘息发作3次或3次以上)急性期血清Eotaxin、sICAM-1浓度与哮喘组比较差异无统计学意义(P>0.05),比喘息Ⅱ组(喘息仅发作1次)高差异有统计学意义(P<0.01);恢复期血清Eotaxin浓度与哮喘组比较差异无统计学意义(P>0.05),血清sICAM-1浓度较哮喘组低。哮喘组急性发作期、慢性持续期血清Eotaxin、sICAM-1浓度两者互呈正相关性(P<0.01);病毒相关性喘息组急性期、恢复期血清Eotaxin、sICAM-1浓度两者互呈正相关性(P<0.01)。结论:①Eotaxin和sICAM-1参与了哮喘和病毒相关性喘息急性发病的过程。②反复喘息患儿慢性炎症持续存在,Eotaxin可作为早期干预的重要指标之一。③病毒相关性喘息患儿与血清Eotaxin和sICAM-1浓度有关,Eotaxin和sICAM-1浓度变化可能有助于预测病毒相关性喘息发展成哮喘的指标之一。
Objective: To detect the concentrations of serum Eotaxin and sICAM-1 in children with bronchial asthma and virus-related wheeze, and to study the relationship between serum Eotaxin and sICAM-1 in high risk patients with recurrent wheezing. Methods: 60 cases of bronchial asthma group and virus-related asthmatic group were randomly selected according to the unified standard set by the Respiratory Group of Pediatric Society of China. Serum and virus-related asthmatic group were used in acute phase and acute phase of bronchial asthma group Serum was taken during the recovery period, and serum Eotax-in and sICAM-1 concentrations were detected by enzyme linked immunosorbent assay. The relationship between serum Eotaxin and sICAM-1 levels and wheezing risk factors was analyzed in 60 children with virus-associated wheeze and 1-year follow-up. Results: Serum levels of Eotaxin and sICAM-1 in the virus-related wheeze group were higher than those in the recovery group (P <0.01). Serum levels of Eotaxin and sICAM-1 in asthmatic group A (wheezy episode three or more times) There was no significant difference between the two groups (P> 0.05), but there was a significant difference between the two groups (P <0.01). Compared with asthma group, there was no significant difference in serum Eotaxin concentration (P> 0.05). Serum sICAM-1 levels were lower than those in asthma group. Serum levels of Eotaxin and sICAM-1 in the asthma group were positively correlated with those in the chronic phase (P <0.01). The levels of Eotaxin and sICAM-1 in the acute phase and convalescent phase of the virus-associated asthmatic group were positively correlated with each other (P <0.01). Conclusion: ①Eotaxin and sICAM-1 are involved in the pathogenesis of asthma and virus-related wheezing. ② chronic asthmatic children with recurrent wheezing persist, Eotaxin can be used as one of the important indicators of early intervention. (3) The serum levels of Eotaxin and sICAM-1 in children with virus-related wheeze are related to the changes of Eotaxin and sICAM-1 concentrations, which may be helpful in predicting the development of virus-associated wheezing into asthma.