[目的 ]探讨I期乳腺癌淋巴结中微小转移与临床预后因素的关系。 [方法 ]分别以抗上皮细胞膜单克隆抗体为探针 ,对 5 2例I期乳腺癌中微小转移进行研究。 [结果 ]有 2 3%病例伴有微小转移。在低分化乳腺癌组中微小转移为 4 5 % ,阳性率明显高于高分化组 (9.3% ) (P <0 0 1)。 [结论 ]免疫组化可大大提高乳腺癌微小转移检出率 ,对临床治疗有着重要意义 [Objective] To investigate the relationship between micrometastasis in lymph node and clinical prognostic factors in stage I breast cancer. [Methods] The anti-epithelial cell membrane monoclonal antibodies were used as probes to study the micrometastasis in 52 cases of stage I breast cancer. [Results] There were 23% cases with micrometastasis. In poorly differentiated breast cancer group micrometastasis was 45%, the positive rate was significantly higher than the well-differentiated group (9.3%) (P <0.01). [Conclusion] Immunohistochemistry can greatly improve the detection rate of micrometastases in breast cancer, which is of great significance for clinical treatment