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为了解cAMP与cGMP在新生儿缺氧缺血性脑病（HIE）中的作用，本文应用放射免疫分析法检测了37例患儿血浆及脑脊液（CSF）中cAMP、cGMP含量，其中轻度8例、中度18例、重度11例，结果表明HIE时CSF中cAMP含量较对照组明显升高（P<0．01），中、重度恢复期较急性期明显下降，而cGMP除轻度外轻对照组明显下降，恢复期较急性期升高；血浆中cAMP水平均较对照组升高（P<0.01），恢复期屯较急性期下降，cGMP与对照组无差异。结果提示cAMP、cGMP与HIE的发病相关。
In order to understand the role of cAMP and cGMP in neonatal hypoxic-ischemic encephalopathy (HIE), the levels of cAMP and cGMP in plasma and cerebrospinal fluid (CSF) of 37 children were detected by radioimmunoassay, of which 8 were mild , Moderate in 18 cases and severe in 11 cases. The results showed that the level of cAMP in CSF of HIE was significantly higher than that of the control group (P <0.01), and the recovery rate of moderate and severe period was significantly lower than that of the acute phase The levels of cAMP in plasma were significantly higher than those in control group (P <0.01). The levels of cAMP in control group were lower than those in acute phase. There was no difference between cGMP group and control group. The results suggest that cAMP, cGMP and HIE incidence.