BIODISTRIBUTION相关论文
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In vivo assessment of hepatotoxicity, nephrotoxicity and biodistribution using 3-aminopropyltriethox
The biocompatibility and biodistdbution of magnetic nanoparticles (MNPs) in vivo are essential to ensure their safe clin......
Boron neutron capture therapy (BNCT) is a binary cancer treatment based upon the high propensity of the nonradioactive n......
Successful accumulation of drugs specifically at diseased sites is mainly limited by biological barriers to drug transpo......
Successful oral delivery of therapeutic proteins such as insulin can greatly improve the quality of life of patients.Thi......
Submicron emulsions (SEs) is an advanced formulation that possesses good biocompatibility, high loading of hydrophobic d......
Objective: Labeling of the dendrimer nanomaterial—polyamidoamine (PAMAM) with 125I and study its biodistribution in mic......
Construction and anti-tumor mechanism of novel polymeric micelles for targeted intracellular drug de
Objective: The aim of our study is to develop novel polymeric micelles to achieve specific tumor targeting and rapid int......
Paramagnetic hollow silica nanospheres for in vivo targeted ultrasound and magnetic resonance imagin
A series of hollow silica nanospheres (HSNSs) with sizes ranging from 100 to 400 nm were synthesized and used for primar......
Effect of molecular weight of chitosan backbone and substitution degree of alkyl chains on the forma
Amphiphilically modified chitosan, N-octyl-N, O-carboxymethyl chitosan (OCC), exhibited good water solubility under neut......
以1，4，7，10-四氮环十二烷和亚磷酸为原料合成1，4，7，10-四膦酸亚甲基1，4，7，10四氮杂环十二烷(DOTMP)； 通过反应堆辐照176Lu2O3天然靶，反应堆中......
Water-soluble quantum dots (QDs) are effective reagents,have minimal toxicity,are compatible with biological system,and ......
The clinically used contrast agents(CAs)are based on the molecule iodinated and gadolinium compounds,limit their applica......
Radiolabeling LyP-1 peptide and preliminary biodistribution evaluation in mice bearing MDA-MB-435 xe
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Preliminary radioimmunoimaging and biodistribution of 131iodine-labeled single-chain antibody fragme
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目的探讨放射性同位素示踪技术在生物药临床研究中的应用价值。方法对3名健康志愿者静脉滴注131I标记的国际一类新药美珀珠单抗，通......
The contribution of absorption of integral nanocrystals to enhancement of oral bioavailability of qu
In this study,self-discriminating hybrid nanocrystals was utilized to explore the biological fate of quercetin hybrid na......
In vivo testing of mucus-permeating nanoparticles for oral insulin delivery using Caenorhabditis ele
The aim was to evaluate the potential of mucus-permeating nanoparticles for the oral admin-istration of insulin.These na......
通过尾静脉注射给药方式研究UO22＋在小鼠体内的分布,通过建立包含主要体液的金属离子、小分子配体及UO22＋及其配合物的热力学函数的......
A Novel Technique for the Preparation of 12sI-5-trimethylstannyl1-(2-deoxy-2-fluoro-beta-D-arabino-f
In this study,a novel technique for the preparation of 125I-5-trimethylstannyl1-(2-deoxy-2-fluoro-beta-D-arabinofuranosy......
Carbon nanomaterials offer excellent prospects as therapeutic agents,and among them,graphene quantum dots (GQDs) have ga......
目的 改进美国CTI公司11C-乙酸盐(11C-AC)自动合成模块流程,提高产量稳定性;用小鼠体内分布、小鼠和正常人体显像验证改进后产品的......
用188W/188Re发生器淋洗得到的188Re示踪剂分别制备了无载体和有载体的188Re-AEDP(1-氨基-亚乙基-1,1-二膦酸)，研究了这两种标记化......
近年来脂质纳米粒由于其优越的特征备受青睐.本文通过腹腔注射评价了双氢青蒿素纳米结构脂质载体在荷S180瘤小鼠体内的抗肿瘤作用,......
目的探讨锝99m(99mTc)标记抗烟曲霉单抗Mab-WF-AF-1的方法,观察标记物体外特性以及在正常小鼠体内生物学分布的特点。方法采用间接......
,Biodistribution and pharmacokinetics of 99mTc-CQDO and 99mTc-CQDO-MeBfor new myocardial imaging age
A comparison of 99mTc-CQDO and 99mTc-CQDO-MeB has been made for biodistribution and pharmacokinetics. 99mTc-CQDO and its......
99mTc-HMIBP, a new bone-imaging agent, was prepared by the reduction of 99mTc-pertechnetate in the were more than 10 μg......
Animal biodistribution,safety and validation study of dopamine transporter PET imaging agent 18F-FEC
This work was to investigate the pharmacologic characteristics of 18F-FECNT (2β-carbomethoxy-3β-(4-chlorophenyl)-8-(2-......
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,Synthesis and biological evaluation of 18F-FB-NGA as a hepatic asialoglycoprotein receptor PET imag
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ADAM (2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine) is suggested as a promising serotonin transporter (SE......
,Biodistribution study of [61Cu] pyruvaldehyde-bis (N-4-methylthiosemicarbazone) in normal rats as a
[61Cu]-labeled pyruvaldehyde-bis (N-4-methylthiosemicarbazone) (61Cu-PTSM), a promising agent made for imaging blood per......
,Radiosynthesis and biodistribution of [18F]-tetracosactide using a semi-automated [18F]SFB producti
In order to prepare a specific melanocortin type 2 receptor (MC2R) ligand, b1-24-corticotrophin was pre-pared in one-ste......
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Technetium-99m-labeled-5-{2-sulfanylethyl-[2-(2-sulfanylethylamino)acetyl]amino}-methyl-2′-deoxy- uridine (99mTc-ANMdU)......
Aim: To investigate the preparation, in vitro release, in vivo pharmacokinetics and tissue distribution of a novel polym......
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A dodecapeptide EDIKPKTSLAFR ligand targeting CEN- 1 human nasopharyngeal carcinoma (NPC) was identified by in vivo phag......
本文通过对荣华二采区10...
Objective: To label avidin (Av) or streptavidin (SA) with 153Sm by taking advantage of the high binding affinity of biot......
目的探讨新型分子探针99 mTc-RRL的药代动力学及急性毒性作用。方法用一步法制备分子探针99 mTc-RRL,在健康小鼠体内进行99 mTc-RR......
Radiolabeling LyP-1 peptide and preliminary biodistribution evaluation in mice bearing MDA-MB-435 xe
Background Recent studies have shown the LyP-1 peptide can home to either tumor lymphatics or the tumor cells and be int......
Preliminary radioimmunoimaging and biodistribution of 131iodine-labeled single-chain antibody fragme
Background Monoclonal antibodies (mAbs) such as DD3,raised against progastrin-releasing peptide(31-98) (ProGRP(31-98)) a......
目的建立一种由γ计数仪测定放射性肿瘤显像剂锝[99mTc]标记的联肼尼克酰胺-3聚乙二醇-精氨酸-甘氨酸-天冬氨酸环肽二聚体(99mTc-3......
Polymersomes scalably fabricated via flash nanoprecipitation are non-toxic in non-human primates and
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
