论文部分内容阅读
目的通过试验观察头低位-头高位反复体位改变模式对人体立位耐力的影响和心血管系统的调节机制。方法选取12名健康男性志愿者,年龄(30±5)岁,身高(170±3)cm,体质量(67.0±2.5)kg进行反复体位改变试验。实验前后测量立位耐力,测量过程中实时监测心电图(ECG)、血压(BP)、心率(HR)、每搏量(SV)、心输出量(CO)、总外周阻力(TPR)等指标。取测量前后平卧位5 min的最后30 s数据以及立位第1个10 s、第2个10 s和第3个10 s的数据进行分析,所有数据均以±s表示,应用SPSS 17.0软件中的配对t检验法对各心血管指标是否存在显著性差异进行验证,以P<0.05为差异有统计学意义。结果实验过程中,所有志愿者未见心电图异常。分析前后平卧位的数据可见,除SV(P=0.019)显著降低外,其余均无显著差异。分析前后立位耐力的第1个10 s的数据可见SBP(P=0.024)和SV(P=0.000)显著性降低,HR(P=0.037)则显著性升高,DBP、MBP、CO和TPR未见显著性变化。前后立位耐力的第2个10 s的数据显示HR(P=0.006)、SV(P=0.0 01)出现显著性差异,SBP、DBP、M BP、CO和TPR未见显著性变化。前后立位耐力的第3个10 s的数据显示HR(P=0.000)、SV(P=0.010)出现显著性差异,SBP、DBP、MBP、CO和TPR未见显著性变化。结论 (1)头低位-头高位反复体位改变试验后,人体立位耐力呈现下降趋势;(2)SBP、SV和心率的显著性变化说明心脏自身调节在立位耐力的血压调节中发挥着重要作用;(3)各种调节因素的时限也存在差异,SBP调节主要集中在体位变化后的第1个10 s内,而HR、SV则持续了体位改变后的整个30 s。
Objective To observe the impact of head low position - head high position repeated position change pattern on standing position endurance and cardiovascular system regulation mechanism. Methods Twelve healthy male volunteers were selected and aged (30 ± 5), height (170 ± 3) cm and body weight (67.0 ± 2.5) kg, respectively. The standing endurance was measured before and after the experiment. The electrocardiogram (ECG), blood pressure (BP), heart rate (HR), stroke volume (SV), cardiac output (CO) and total peripheral resistance (TPR) were measured in real time during the measurement. The data of the last 30 seconds before and after the 5-minute test of the supine position and the first 10 seconds, the second 10 seconds and the third 10 seconds of the data were analyzed. All the data were expressed as ± s. SPSS 17.0 software In the paired t test for the cardiovascular indicators of the existence of significant differences were verified to P <0.05 for the difference was statistically significant. Results During the experiment, no ECG abnormalities were observed in all volunteers. Before and after the analysis of supine data can be seen, in addition to SV (P = 0.019) decreased significantly, the rest were no significant differences. The first ten seconds before and after standing stand were analyzed. The SBP (P = 0.024) and SV (P = 0.000) were significantly decreased, HR (P = 0.037) was significantly increased, DBP, MBP, CO and TPR No significant change. The first 10 seconds before and after the standing endurance data showed HR (P = 0.006), SV (P = 0.0 01) showed significant differences, SBP, DBP, M BP, CO and TPR no significant changes. The first 10 s of anterior and posterior standing endurance data showed significant differences in HR (P = 0.000), SV (P = 0.010), and no significant changes in SBP, DBP, MBP, CO and TPR. Conclusions (1) The change of SBP, SV and heart rate showed a downward trend after repeated head-to-head postural change test. (2) The significant changes of SBP, SV and heart rate indicate that heart self-regulation plays an important role in blood pressure regulation of standing endurance (3) there are differences in the timing of various regulatory factors, SBP regulation mainly concentrated in the first 10s after the change in position, while HR, SV continued the post-change the whole 30s.