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作者对５８例正常足月妊娠拟行择期剖宫产术的孕妇，于术前３～４小时经母体静脉（静脉组）及羊膜腔内（羊膜腔组）分别输入等量复方氨基酸液，与对照组（不输任何药物）对比，观察母血及胎儿脐血（脐动脉和静脉）中游离氨基酸水平。结果：静脉组中母血及胎儿脐血的游离氨基酸及总氨基酸水平高于对照组（Ｐ＜０．０５），但胎儿对多数氨基酸的吸收无明显增加（Ｐ＞０．０５）；羊膜腔组中胎儿脐血的游离氨基酸及总氨基酸水平高于静脉组和对照组（Ｐ＜０．０５），胎儿对氨基酸的吸收增加（Ｐ＜０．０５）。两种途径给药对胎儿脐动脉血ｐＨ、ＰＯ＿２、ＰＣＯ＿２均无影响（Ｐ＞０．２）。羊膜腔内输注氨基酸前后其内压力无明显改变（Ｐ＞０．２）．我们研究的结果初步表明羊膜腔内给药对于胎儿宫内生长发育迟缓（ＩＵＧＲ），尤其是有严重胎盘功能障碍者有望成为一种有效的治疗途径。
The author of 58 normal full-term pregnant women planned elective cesarean delivery of pregnant women, 3 to 4 hours before surgery by the mother vein (vein group) and amniotic cavity (amniotic cavity group) were entered the same amount of compound amino acid solution, and The control group (without any drug) contrast, observe the maternal blood and fetal cord blood (umbilical artery and vein) free amino acid levels. Results: The free amino acids and total amino acids of maternal blood and fetal umbilical cord blood in the venous group were higher than those in the control group (P <0.05), but the absorption of most amino acids in the fetus did not increase significantly (P> 0.05) The free amino acids and total amino acid levels of fetal cord blood were higher in the group than those in the vein group and the control group (P <0.05). The fetus’s amino acid absorption increased (P <0.05). Both routes of administration had no effect on fetal umbilical arterial pH, PO 2, PCO 2 (P> 0.2). Amniotic cavity before and after the infusion of amino acids had no significant change (P> 0.2). Preliminary results of our study indicate that intra-amniotic administration is expected to be an effective therapeutic approach for IUGR, especially severe placental dysfunction.