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本研究通过肌注氯化锌的动物实验，主要进行锌通过胎盘屏障和血脑屏障从母体转运到胎体的研究。实验采用原子吸收法测定母体和胎体组织中锌、铜、铁的含量，用ＳｅｐｈａｄｅｘＧ－７５柱分析法测定金属硫蛋白（ＭＴ）的含量。结果表明，经皮下注射的无机锌，能迅速经母血转运到母体的肝脏、肌肉及胎盘，实验组与对照组之间差别显著，不同孕期的实验组间锌含量无显著性差异。在早孕阶段，锌能通过胎盘屏障转运到胚胎，实验组和对照组问有显著的差异（Ｐ＜０．０１），中孕阶段，实验组胎脑中的锌含量比对照组也有增高的趋势。母体肝脏和胚胎ＭＴ的合成受锌的诱导，实验组胚胎ＭＴ（０．４６ｎｍｏｌ／ｇ）约是对照组（０．１０ｎｍｏｌ／ｇ）的４．５倍。推测ＭＴ在锌的转运中起重要作用。
In this study, intramuscular injection of zinc chloride animal experiments, the main zinc transport through the placental barrier and the blood-brain barrier from the mother to the carcass. The contents of zinc, copper and iron in maternal and carcass tissues were determined by atomic absorption spectrometry, and the content of metallothionein (MT) was determined by SephadexG-75 column analysis. The results showed that subcutaneously injected inorganic zinc could be quickly transported to maternal liver, muscle and placenta via maternal blood. The difference between experimental group and control group was significant. There was no significant difference in zinc content between experimental groups in different pregnancy stages. In the first trimester of pregnancy, zinc translocated to the embryo through the placental barrier. There was a significant difference between the experimental group and the control group (P <0.01). In the second trimester, the zinc content in the fetal brain of the experimental group also increased compared with the control group . The synthesis of MT from maternal liver and embryo was induced by zinc. The MT of experimental group was about 4.5 times that of control (0.10 nmol / g). It is speculated that MT plays an important role in zinc transport.