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目的:急性肺损伤死亡率高且目前尚无有效可靠的治疗方法,本研究旨在探讨低分子肝素雾化吸入对急性肺损伤的治疗作用。方法:健康纯种白兔24只,随机分成3组(n=8):①正常对照组,②生理盐水雾化组,③低分子肝素雾化治疗组。各组分别测定动脉血气、肺干/湿重比、支气管肺泡灌洗液总蛋白含量和凝血功能。结果:与正常对照组相比,生理盐水雾化组和低分子肝素雾化治疗组动脉血氧合指数、肺干/湿重比值显著降低(P<0.05),支气管肺泡灌洗液总蛋白含量显著升高(P<0.05),而低分子肝素雾化治疗组较生理盐水雾化组动脉血氧合指数、肺干/湿重比值显著升高(P<0.05),支气管肺泡灌洗液总蛋白含量显著降低(P<0.05);凝血酶原时间以及活化部分凝血活酶时间生理盐水雾化组和低分子肝素雾化治疗组间没有显著差异(P>0.05),但均较正常对照组延长(P<0.05)。结论:低分子肝素雾化吸入治疗可以改善肺换气,提高氧合,降低肺泡渗出,并且对凝血功能没有明显的副作用,可以在一定程度上缓解急性肺损伤。本研究为急性肺损伤的治疗提供了新的思路和实验依据。
OBJECTIVE: There is no effective and reliable treatment for acute lung injury with high mortality rate. This study aimed to investigate the therapeutic effect of low molecular weight heparin inhalation on acute lung injury. Methods: Twenty-four healthy purebred white rabbits were randomly divided into three groups (n = 8): ① normal control group, ② saline nebulization group, ③ low molecular weight heparin atomization treatment group. The arterial blood gas, lung dry / wet weight ratio, total protein content of bronchoalveolar lavage fluid and coagulation function were measured in each group. Results: Compared with the normal control group, the arterial oxygenation index and the ratio of pulmonary dry weight / wet weight decreased remarkably (P <0.05) in the atomized group and low molecular weight heparin group. The total protein content of bronchoalveolar lavage fluid (P <0.05). However, the arterial oxygenation index and the ratio of pulmonary dry weight / wet weight in low molecular weight heparin atomization group were significantly higher than those in saline nebulization group (P <0.05). The total bronchoalveolar lavage fluid (P <0.05). There were no significant differences in prothrombin time and activated partial thromboplastin time between saline nebulization group and low molecular weight heparin atomization group (P> 0.05), but both were significantly higher than those in normal control group Extended (P <0.05). Conclusion: Low molecular weight heparin inhalation therapy can improve lung ventilation, improve oxygenation, reduce alveolar exudate, and no obvious side effects on coagulation, which can relieve acute lung injury to some extent. This study provides a new idea and experimental basis for the treatment of acute lung injury.