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本文研究了~3H标记的紫草素(shikonin)在小鼠体内的代谢。静脉注射~3H紫草素后,血浆消除相半衰期(T 1/2β)为8.79 h,分布容积(V_d)为8.91 L/kg。静脉注射后胆汁及肝中含量最高,肺、脾、肾、心、皮肤中等,睾丸,肌肉、脑含量最低。肌肉注射及灌胃后吸收迅速,血浆浓度达峰时间分别为7.62min和5.78 min。静脉注射后,仅有小部分以原形药从屎及粪排出,大部分以转化形式排出。
This article investigated the metabolism of 3H-labeled shikonin in mice. After intravenous injection of ~ 3H shikonin, the plasma elimination phase half-life (T 1 / 2β) was 8.79 h, and the volume of distribution (V_d) was 8.91 L / kg. After intravenous injection, the content of bile and liver is the highest, with the lowest content of lung, spleen, kidney, heart, skin, testis, muscle and brain. Intramuscular injection and intragastric absorption quickly, the peak plasma concentrations of time were 7.62min and 5.78 min. After intravenous injection, only a small portion of the prototype drug excretion from feces and feces, most of the discharge in the form of conversion.