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目的:通过检测系统性红斑狼疮(SLE)患者外周血中IL-17的水平,探讨其临床意义。方法:用酶联免疫吸附法(enzymelinked immunosorbent assay,ELISA)检测61例SLE患者及30例健康人血清IL-17水平,并收集整理SLE患者的临床资料及实验室数据,分析其与临床的关系。结果:活动期SLE患者血清IL-17水平明显高于正常对照组(P<0.01),与SLE非活动组相比,差异亦有统计学意义(P<0.01)。但SLE非活动组与正常对照组间无统计学意义。结论:IL-17水平在活动期SLE患者血清中表达明显增高,且与SLEDAI评分呈正相关,提示IL-17可能参与了SLE疾病的病理过程,可能与疾病活动的关系密切。
Objective: To investigate the clinical significance of IL-17 in peripheral blood of patients with systemic lupus erythematosus (SLE). Methods: Serum IL-17 levels were measured by enzyme linked immunosorbent assay (ELISA) in 61 SLE patients and 30 healthy controls. The clinical data and laboratory data of patients with SLE were collected and analyzed, and their relationship with clinical . Results: The level of serum IL-17 in active SLE patients was significantly higher than that in normal controls (P <0.01). There was also a significant difference (P <0.01) between SLE patients and active SLE patients. However, SLE non-active group and the normal control group was not statistically significant. CONCLUSION: The level of IL-17 in sera of patients with active SLE is significantly increased, and positively correlated with SLEDAI score, suggesting that IL-17 may be involved in the pathological process of SLE and may be closely related to disease activity.