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目的:了解夫妇ABO血型不合的孕妇血清中IgG抗-A(B)效价异常率及临床意义。方法:采用回顾性分析方法分析ABO-新生儿溶血病(HDN)患儿的胆红素水平与新生儿黄疸患儿的差异,并追溯其母亲年龄、产检时血型血清抗体效价及父亲血型,分析其与发病率之间关系。结果:ABO-HDN导致的新生儿黄疸与其他原因导致的新生儿黄疸患儿总胆红素和间接胆红素水平间差异无统计学意义(P>0.05);74例患儿母亲血型血清抗体效价中有40人异常,占总人数的54.05%;比较父亲血型,A、B型血型的父亲HDN发病率高于AB型(29%∶32%∶13%),但AB血型的父亲其妻子抗体效价更高(61.54%∶53.12%∶51.72%)。结论:在产前保健孕妇中进行ABO血型抗体效价检测,及早发现异常及时治疗,可减少由于母婴血型不合引起的HDN的发生。
Objective: To investigate the abnormal rate of IgG anti-A (B) titer in the serum of couples with ABO incompatible and their clinical significance. Methods: The differences of bilirubin levels in neonates with neonatal jaundice and children with ABO-neonatal hemolytic disease (HDN) were analyzed retrospectively. The age of their mothers, serum antibody titers at the time of delivery and their blood type, Analysis of the relationship between the incidence. Results: There was no significant difference between neonatal jaundice caused by ABO-HDN and other causes of neonatal jaundice between total bilirubin and indirect bilirubin (P> 0.05); 74 cases of mother’s blood serum antibody There were 40 abnormalities in the titer, accounting for 54.05% of the total. Compared with father’s blood group, fathers of type A and B had higher incidence of HDN than those of AB (29%: 32%: 13%), but father of AB Wife antibody titers higher (61.54%: 53.12%: 51.72%). Conclusion: Detection of antibody titer of ABO blood group in prenatal care pregnant women and early detection of abnormal and timely treatment can reduce the occurrence of HDN caused by maternal-fetal blood group incompatibility.