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目的:探讨癌糖类抗原125(CA125)、甲种胎儿球蛋白(AFP)及绒毛膜促性腺激素(β-HCG)联合检测对卵巢癌的诊断价值。方法:116例卵巢癌以化学发光法分别测定CA125、AFP及β-HCG。结果:CA125、AFP及β-HCG检测总阳性率为90.52%,其中卵巢癌患者中CA125、AFP及β-HCG阳性率分别为72.41%、9.48%及8.62%。CA125在卵巢浆液性腺癌、内胚窦癌中的阳性率为96.77%和75.00%,5例卵巢癌术后CA125阳性者均已复发。内胚窦癌AFP阳性率为56.25%。内胚窦癌及浆液性腺癌患者中β-HCG阳性率分别为12.50%及9.68%。结论:CA125对卵巢浆液性腺癌、子宫内膜样癌及内胚窦癌具有较高的诊断价值和预示预后的意义。AFP和β-HCG对内胚窦癌具有特异性诊断意义。CA125、AFP及β-HCG联合检测可提高卵巢癌的检出率。
Objective: To investigate the diagnostic value of combined detection of CA125, AFP and β-HCG in ovarian cancer. Methods: 116 cases of ovarian cancer chemiluminescence were measured CA125, AFP and β-HCG. Results: The positive rates of CA125, AFP and β-HCG were 90.52%. The positive rates of CA125, AFP and β-HCG in ovarian cancer patients were 72.41%, 9.48% and 8.62% respectively. The positive rates of CA125 in ovarian serous adenocarcinoma and endodermal sinus cancer were 96.77% and 75.00%, respectively. All of the 5 CA125 positive patients with ovarian cancer had recurred. The positive rate of AFP in endodermal carcinoma was 56.25%. The positive rates of β-HCG in endodermal and serous adenocarcinoma were 12.50% and 9.68% respectively. Conclusion: CA125 has high diagnostic value and prognostic significance in ovarian serous adenocarcinoma, endometrioid carcinoma and endodermal sinus cancer. AFP and β-HCG endometrial cancer has specific diagnostic significance. Combined detection of CA125, AFP and β-HCG can improve the detection rate of ovarian cancer.