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本研究用双抗体夹心ＥＬＩＳＡ法检测７２例不育男性和２０例正常对照精浆白细胞介素－８（ＩＬ－８）水平。不育组ＩＬ－８水平明显高于正常对照组（Ｐ＜０．００１），其中，白细胞＞４个／ＨＰ精液组明显高于对照组（Ｐ＜０．００１），白细胞≤４个／ＨＰ精液组与对照组无明显区别（Ｐ＞０．０５）。白细胞＞４个／ＨＰ组精液中白细胞数与精浆ＩＬ－８呈正相关（ｒ＝０．８８３，Ｐ＜０．００１）。而且治疗前、后精浆ＩＬ－８浓度有明显差异，且与精液白细胞下降同步。ＩＬ－８是反映生殖系统感染的诊断及疗效判断的良好指标。
In this study, 72 cases of infertile men and 20 cases of normal control seminal plasma interleukin-8 (IL-8) levels were detected by double antibody sandwich ELISA. The level of IL-8 in infertility group was significantly higher than that in the normal control group (P <0.001), of which the number of white blood cells> 4 / HP semen group was significantly higher than that of the control group (P <0.001) Semen group and control group no significant difference (P> 0.05). White blood cells> 4 / HP semen white blood cell count and seminal plasma IL-8 was positively correlated (r = 0.883, P <0.001). And before and after treatment, seminal plasma IL-8 concentrations were significantly different, and synchronized with the decline of semen leukocytes. IL-8 is a good indicator of the diagnosis and efficacy of reproductive system infection.