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目的：了解慢性肾功能衰竭（CRF）患者外周血T淋巴细胞亚群及可溶性白细胞素Ⅱ受体（sIL－2R）的变化及意义。方法：采用免疫细胞化学ABC间接法及双抗体夹心ELISA法。结果：①CRF患者外周血CD(3＋)、CD(4＋)、CD(8＋)细胞、CD(4＋)／CD(8＋)比值均显著低于正常对照组（P＜0．05～0．01），与Scr、GFR无相关性；②血清sIL－2R含量较对照组显著增高（P＜0．01），与Scr呈显著正相关，GFR是显著负相关。结论：CRF患者存在免疫功能异常的病理改变，免疫调节剂的使用可能有助于延缓CRF的进展。
Objective: To investigate the changes of peripheral blood T lymphocyte subsets and soluble interleukin 2 receptor (sIL-2R) in patients with chronic renal failure (CRF) and its significance. Methods: Immunocytochemistry ABC indirect method and double antibody sandwich ELISA method. Results: ① The ratio of CD (3 +), CD (4 +), CD (8+) cells and CD (4 +) / CD (8+) in peripheral blood of patients with CRF were significantly lower than those of the normal control group (P <0.05-0.01) , But no correlation with Scr and GFR. (2) Serum sIL-2R level was significantly higher than that of the control group (P <0.01), and was positively correlated with Scr and GFR was negatively correlated. CONCLUSIONS: There are pathological changes in immunocompromised CRF patients. The use of immunomodulatory agents may help to delay the progression of CRF.