小管-间质性肾病是指病变累及肾小管及间质,而出现水、电解质、酸碱平衡紊乱的一组疾病。本组疾病最后导致肾功能衰竭者约占慢性肾功能衰竭总数的25％。表明这类疾病很常见,其重要性不亚于肾小球疾病。小管-间质性肾病有原发性与继发性之分,但其病因大体可分为五类:①毒素、毒物直接损害肾小管及肾间质;②触发肾小管间质的免疫反应;③肾内血流动力学改变;④肾内微循环障碍;⑤集合管系统梗阻。尽管这些肾损害的病因、发病机理及病 Tubules - interstitial nephropathy refers to the lesions involving the tubules and interstitium, and the emergence of water, electrolyte, acid-base balance disorders of a group of diseases. This group of diseases eventually lead to renal failure accounted for about 25% of the total number of chronic renal failure. Show that these diseases are common, its importance as much as glomerular disease. Tubules - interstitial nephropathy have primary and secondary points, but its causes can be broadly divided into five categories: ① toxins, toxins directly damage the tubules and renal interstitium; ② trigger tubulointerstitial immune response; ③ renal hemodynamic changes; ④ renal microcirculation; ⑤ collection tube system obstruction. Despite these kidney damage etiology, pathogenesis and disease