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本文测定了41例急性白血病（AL）患儿在发病初期、部分缓解期及完全缓解期血清丙二醛（MDA）含量及猛──超氧化物歧化酶（Mn──SOD）活力，并与21例正常儿童进行对比分析，发现血清MDA含量在发病初期明显升高（P〈O．01），部分缓解期有所下降，完全缓解期接近正常水平（P＞0．05）。Mn──SOD活力在发病初期则明显下降（P＜0．01），部分缓解期有所回升，完全缓解期呈继续上升趋势，但尚未达正常水平（P＜0．05）。本研究提示自由基──脂质过氧化参与了小儿AL的发生、发展；Mn──SOD活力改变与肿瘤形成有密切关系；血清MDA与Mn──SOD的动态观察有利于了解疾病的转归。
In this study, the serum levels of malondialdehyde (MDA) and fierce superoxide dismutase (Mn-SOD) were measured in 41 children with acute leukemia (AL) at early onset, partial remission and complete remission 21 cases of normal children were compared and found that serum MDA levels increased significantly in the early onset (P <0.01), partial remission decreased, complete remission close to normal levels (P> 0.05). Mn-SOD activity decreased significantly in the early stage of disease (P <0.01), partial remission rose, and complete remission continued to increase but not reached the normal level (P <0.05). This study suggests that free radicals ─ ─ lipid peroxidation involved in the occurrence and development of AL in children; Mn ─ ─ SOD activity changes and tumor formation are closely related; serum MDA and Mn ─ ─ SOD dynamic observation is conducive to understanding the outcome of the disease .