Muzolimine是一种新的有效利尿剂,结构上与当前使用的有效利尿剂不相同。在动物和人的研究中发现它作用于亨利氏攀升支,口服后血浆浓度迅即可达高峰。由于半衰期长,所以作用时间也较长。对肾功能无影响。本文介绍的Muzolimine,于24例慢性肾功能衰竭患者中(其肌酐的廊清率为4—28ml/分)口服以治疗浮肿或高血压或同时有浮肿与高血压的患者。其中4例系静注大剂量速尿无效后用药的。结果,尿量明显增加,钠、氯、钾的排泄增多。全部病例水肿消退,平均体重减轻8％。停药后无反跳现象。7例高血压者中的5例,以前用抗高血压药无效的11例中的 Muzolimine is a new and effective diuretic that is structurally different from currently available effective diuretics. In animal and human studies it is found that it acts on Henry’s Climbing Branch and plasma levels reach its peak immediately after oral administration. As the half-life is long, so the role of time is longer. No effect on renal function. This article describes the Muzolimine in 24 patients with chronic renal failure (its creatinine rate of 4-28ml / min) at oral administration to treat edema or high blood pressure or both edema and hypertension in patients. 4 cases of intravenous injection of high-dose furosemide ineffective medication. As a result, urine output increased significantly, sodium, chlorine and potassium excretion increased. All cases edema subsided, the average weight loss of 8%. No rebound after withdrawal. Five of the seven hypertensive patients were previously excluded from the antihypertensive medication