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目的探讨Meek植皮,莫匹罗星软膏联合碱性成纤维细胞生长因子(acidic Fibroblast Growth Factor,b-FGF)混悬液治疗III°烧伤创面的临床疗效和安全性。方法选取2013-01—2015-01间内江市第一人民医院收治的36例III°烧伤患者的临床资料进行回顾性分析,分别采用Meek植皮联合莫匹罗星软膏治疗和Meek植皮,莫匹罗星软膏联合b-FGF混悬液治疗,观察并比较其临床疗效和不良反应发生情况。结果观察组创面愈合时间和皮片融合时间低于对照组,而皮片成活率高于对照组,差异有统计学意义(P<0.05);两组均未发生感染、过敏反应等不良反应,各1例出现渗血及渗液,换药治疗后缓解,差异无统计学意义(P>0.05)。结论在Meek植皮基础上,联合莫匹罗星和b-FGF混悬液治疗III°烧伤创面安全有效,临床应用前景广阔。
Objective To investigate the clinical efficacy and safety of Meek skin graft and mupirocin ointment in combination with suspension of basic fibroblast growth factor (b-FGF) in the treatment of III degree burn wounds. Methods The clinical data of 36 cases of III ° burns treated in Neijiang First People’s Hospital from January 2013 to January 2015 were retrospectively analyzed. Meek skin grafting combined with mupirocin ointment and Meek skin grafting, Star ointment combined with b-FGF suspension treatment, observe and compare the clinical efficacy and adverse reactions. Results The wound healing time and skin fusion time of the observation group were lower than those of the control group, while the survival rate of the skin graft was higher than that of the control group (P <0.05). No adverse reactions such as infection and allergic reaction occurred in both groups, The bleeding and exudation occurred in 1 case and relieved after dressing change, the difference was not statistically significant (P> 0.05). Conclusion The combination of mupirocin and b-FGF suspension on the basis of Meek skin grafting is safe and effective in the treatment of III ° burn wounds. The clinical application is promising.