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目的了解重庆市万州区在园儿童手足口病病原携带情况,为分析手足口病发病规律、科学防控提供参考依据。方法采用随机抽样的方式,采集不同季节、城市与农村健康在园儿童肛拭子标本,以荧光RT-PCR法检测手足口病肠道病毒通用型(EV)、肠道病毒71型(EV71)、柯萨奇病毒CA16、CA6、CA10型。结果 1 276份标本检出EV核酸阳性211份,阳性率为16.54%。其中EV71、CA6、CA16、CA10及HEV分别占13.74%、6.16%、4.74%、1.90%、73.46%。手足口病病毒携带率流行期高于非流行期,差异有统计学意义(χ~2=14.97,P<0.05),农村高于城市,差异有统计学意义(χ~2=9.184,P<0.05),男、女差异无统计学意义(χ~2=0.004 2,P=0.948 2),各年龄组差异有统计学意义(χ~2=36.26,P<0.05)。结论重庆市万州区在园儿童手足口病病原携带率较高,不同区域、季节、年龄组差异有统计学意义,应采取有针对性的防控策略。
Objective To understand the pathogen carrier of hand, foot and mouth disease in children in Wanzhou District of Chongqing Municipality for the purpose of analyzing the pathogenesis of hand-foot-mouth disease and providing scientific basis for prevention and control. Methods Random sampling was used to collect swine swab samples from healthy children in different seasons, cities and rural areas. The EV71, EV71, , Coxsackie virus CA16, CA6, CA10 type. Results A total of 211 positive samples were detected in 1 276 specimens, the positive rate was 16.54%. Among them, EV71, CA6, CA16, CA10 and HEV accounted for 13.74%, 6.16%, 4.74%, 1.90% and 73.46% respectively. The prevalence of hand-foot-mouth-mouth disease was higher than that of non-epidemic stage (χ ~ 2 = 14.97, P <0.05), and the difference was statistically significant in rural areas (χ ~ 2 = 9.184, P < 0.05). There was no significant difference between males and females (χ ~ 2 = 0.004 2, P = 0.948 2). There was significant difference among all age groups (χ ~ 2 = 36.26, P <0.05). Conclusion The carrying rate of hand, foot and mouth disease in children in Wanzhou District in Chongqing is higher than that in other regions, seasons and age groups. Therefore, targeted prevention and control strategies should be taken.