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本实验采用3×3析因实验设计,将360只小鼠分成9个实验组,分3个月和6个月两个实验期,以不同浓度的碘、硒单独及联合作用对甲状腺功能、形态结构及甲状腺肿发生和发展的影响进行了探讨。结果:(1)低碘和高碘是甲状腺功能、形态结构及甲状腺肿发生和发展的主要因素;(2)低硒长时间(6个月)作用可促进甲状腺肿的发生,补硒则使甲状腺重量降低,补至高剂量时作用更明显;(3)碘硒交互作用的结果与碘单独作用基本一致。在高碘时,补硒可使甲状腺素(T_4)调剂到适碘组的水平。因此,在对地甲病进行流行病学调查和防治时应重视硒的作用。同时硒对碘性甲亢是否有预防作用值得深入探讨。
In this experiment, 3 × 3 factorial experimental design, the 360 mice were divided into 9 experimental groups, divided into three months and six months of two experimental periods, with different concentrations of iodine, selenium alone and in combination on thyroid function, Morphological structure and the occurrence and development of goiter were discussed. Results: (1) Low iodine and high iodine are the main factors of thyroid function, morphological structure and occurrence and development of goiter; (2) Low selenium prolonged (6 months) can promote the occurrence of goiter; Thyroid weight decreased, up to the role of high doses of more obvious; (3) the results of iodine and selenium interaction and iodine alone is basically the same. In high iodine, selenium can make thyroxine (T_4) adjusted to the appropriate level of iodine group. Therefore, in endemic disease epidemiological investigation and prevention should pay attention to the role of selenium. At the same time selenium on iodine hyperthyroidism whether there is a preventive role worth in-depth discussion.