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目的观察奥卡西平口服混悬液单药治疗对特发性癫痫患儿细胞免疫及体液免疫功能的影响。方法采用定期门诊随访,用药前、用药后3个月、6个月分别采集25例特发性癫痫患儿(癫痫组)及21例健康体检儿童(正常对照组)空腹静脉血以全自动生化分析仪采用免疫比浊法检测血清免疫球蛋白IgG、IgA、IgM及流式细胞分析仪检测CD3、CD4、CD8及ICAM-I。结果癫痫患儿用药前IgA[(0.75±0.42)g/L]、IgG[(7.74±2.65)g/L]、ICAM-1(38.07±12.87)、CD8(19.61±5.52)含量升高,CD3(40.27±9.66)、CD4(20.63±8.97)下降,与正常对照组比较差异有显著性(P<0.05),而IgM[(1.10±0.50)g/L]与正常对照组比较差异无显著性(P>0.05);用药3个月后IgA[(0.29±0.18)g/L]、IgG[(6.66±1.84)g/L]、CD8(16.27±6.53)下降,CD3(50.55±13.35)升高,与用药前比较差异有显著性(P<0.05),与正常对照组比较差异无显著性(P>0.05);用药6个月后IgA[(0.25±0.13)g/L]、IgG[(6.07±1.46)g/L]、CD8(14.22±4.76)、ICAM-1(29.83±10.84)下降,CD4(26.58±9.76)升高,与用药前比较差异有显著性(P<0.05),与正常对照组比较差异无显著性(P>0.05);IgM与正常对照组及用药前比较差异均无显著性(P>0.05)。用药3个月与6个月各指标比较差异无显著性(P>0.05)。结论特发性癫痫患儿用药前即存在细胞免疫及体液免疫功能的紊乱,奥卡西平口服混悬液在控制癫痫发作的同时,可改善癫痫患儿的免疫状态。
Objective To observe the effect of oral administration of oxcarbazepine on cellular immunity and humoral immune function in children with idiopathic epilepsy. Methods Twenty-five cases of idiopathic epilepsy (epilepsy group) and 21 healthy children (normal control group) were collected at regular follow-up, before medication and 3 months and 6 months after treatment. The analyzer used immunoturbidimetric assay to detect serum immunoglobulin IgG, IgA, IgM and flow cytometer to detect CD3, CD4, CD8 and ICAM-I. Results The levels of IgA [(0.75 ± 0.42) g / L], IgG [(7.74 ± 2.65) g / L], ICAM-1 (38.07 ± 12.87) and CD8 (19.61 ± 5.52) in children with epilepsy increased (40.27 ± 9.66) and CD4 (20.63 ± 8.97), respectively. There was significant difference between the two groups (P <0.05), while there was no significant difference between IgM [(1.10 ± 0.50) g / L] and normal control group (P <0.05). IgA [(0.29 ± 0.18) g / L], IgG [(6.66 ± 1.84) g / L], CD8 (16.27 ± 6.53) and CD3 (50.55 ± 13.35) (P <0.05). There was no significant difference between the two groups (P> 0.05). The levels of IgA [(0.25 ± 0.13) g / L] (6.07 ± 1.46) g / L, CD8 (14.22 ± 4.76), ICAM-1 (29.83 ± 10.84) and CD4 (26.58 ± 9.76) respectively. There was a significant difference between the two groups There was no significant difference between normal control group and normal control group (P> 0.05). There was no significant difference between IgM group and normal control group and before treatment (P> 0.05). Drugs 3 months and 6 months of each index was no significant difference (P> 0.05). Conclusions There are disorders of cellular immunity and humoral immune function in children with idiopathic epilepsy before oral administration of epilepsy. The oral suspension of oxcarbazepine can improve the immune status of children with epilepsy while controlling seizures.