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近日,中国农业科学院哈尔滨兽医研究所研究员郑永辉带领的基础免疫创新团队发现,内质网I型α-甘露糖苷酶能够诱导艾滋病病毒囊膜糖蛋白降解,继而抑制艾滋病病毒的复制,最终有望达到治疗的目的。研究成果近期发表于《生物化学杂志》。由于艾滋病病毒感染人体后会在细胞内形成一个潜伏病毒库,在中断治疗后能迅速释放病毒,导致继续感染。因此,临床上治疗艾滋病的药物只能抑制病毒的生长,而不能彻底清除艾滋病患者体内的病毒,致使艾滋病无法得到治愈。艾滋病病毒囊膜蛋白是启动病毒感染的关键蛋白,抑制囊膜糖蛋白的功能具有抗病毒的治疗作用,而直接阻断其在细胞内的合成则能达到
Recently, the basic immunological innovation team led by Zheng Yonghui, a researcher at Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, found that endoplasmic reticulum type I α-mannosidase can induce the degradation of HIV glycoprotein glycoproteins, and then inhibit the replication of HIV, which is finally expected to reach treatment the goal of. The research results recently published in the Journal of Biochemistry. Because HIV infection in the human body will form a latent virus in the cell library, in the interrupt treatment can quickly release the virus, resulting in continued infection. Therefore, the clinical treatment of AIDS drugs can only inhibit the growth of the virus, but can not completely remove the AIDS virus in patients with the virus, resulting in AIDS can not be cured. AIDS virus envelope protein is the key to start the virus infection, inhibit the function of glycoprotein capsule with anti-viral therapeutic effect, but directly blocked in the synthesis of cells can be achieved