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本文报导一项为时12周的双盲对照研究,评价吸入二丙酸氯地米松(Beclomethasone dipropionate)对类固醇依赖性哮喘患者的作用。在12周研究期的前后检查患者的肾上腺功能。23例需要强的松5～20毫克/日的哮喘患者每天吸入氯地米松400毫克或安慰剂,连用12周。强的松剂量在每周评定时根据可能逐渐减量。接受12周安慰剂的患者嗣后改用氯地米松治疗以求进一步减少强的松剂量。研究结果:氯地米松组12例患者中,有9例(75％)在12周研究期间可完全停用强的松,另3例,强的松剂量可减少20～67％。安慰剂组11例患者
This article reports a 12-week, double-blind, controlled study evaluating the effect of inhaled Beclomethasone dipropionate on steroid-dependent asthma. The patient’s adrenal function was examined before and after the 12-week study period. Twenty-three patients with asthma requiring prednisone 5 to 20 mg / day were given 400 mg of beclometasone or placebo daily for 12 weeks. Prednisone dosage may taper off on a weekly basis. Patients receiving placebo for 12 weeks were subsequently treated with beclomethasone to further reduce prednisone dosage. RESULTS: Nine out of 12 patients (75%) in the beclomethasone group were able to discontinue prednisone completely during the 12-week study period, while the other three patients received prednisone 20 to 67% fewer doses. 11 patients in the placebo group