例1:女性,48岁,住院号46539。因全身关节游走性疼痛20年,自1982年至今曾四次住院治疗。近8年来症状加重,四肢肢端遇凉后呈现规律性苍白—发绀—潮红改变,伴口干、厌食、咽下困难。既往健康,无家族遗传病史。1982年首次入院时体检:T37.5℃,P96次/min,R20次/min。Bp12/8kPa。贫血貌,毛发干燥,唇及甲床苍白,面部可见对称性盘状红斑,两肺正常,心尖部可闻及Ⅱ级收缩期 Example 1: Female, 48 years old, hospital number 46539. 20 years of pain due to systemic stenosis, and has been hospitalized for four times since 1982. Over the past eight years, the symptoms worsened, limbs extremities showed regular cold pale - cyanosis - flushing, with dry mouth, anorexia, dysphagia. Past health, no family history of genetic disease. First hospital admission in 1982 physical examination: T37.5 ℃, P96 times / min, R20 times / min. Bp12 / 8kPa. Anemia appearance, dry hair, pale lip and nail bed, the face can be seen symmetrical discoid erythema, both lungs normal, apex can be heard and Ⅱ systolic