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β-受体阻断剂心得安能降低人和动物的基础代谢率,其机制不甚清楚。切除猪的甲状腺,再给予心得安,降低基础代谢率的作用消失。T_4脱碘转变为T_3的过程,受心得安和儿茶酚胺影响,前者为抑制作用,后者则相反。 本文作者选用2～3个月,体重10～15kg的猪进行实验,旨在研究心得安对猪甲状腺激素代谢的影响。动物按60g/kg标准饲养。实验分为生理盐水组和心得安组,所有动物行颈静脉插管以备取血。按Macari氏方法计算T_4和T_3的分次消失速率(K值),再依据K值计算激素的代谢清除率(MCR)和分解速率(CR)。用放免法测定血浆中激素浓度。
Beta-blocker propranolol reduces the basal metabolic rate in humans and animals, the mechanism is not clear. Excision of the pig’s thyroid gland, and then give peace of mind, the role of reducing the basal metabolic rate disappears. T_4 deiodination into T_3 process, by the propranolol and catecholamines affect the former inhibition, the latter is the opposite. The authors selected 2 to 3 months, weighing 10 ~ 15kg pig experiments to study the effect of propranolol on pig thyroid hormone metabolism. Animals according to 60g / kg standard breeding. The experiment was divided into saline group and propranolol group, all animals were jugular vein catheter for blood. Calculate the fractional extinction rate (K value) of T_4 and T_3 according to Macari’s method, and then calculate the hormone’s metabolic clearance rate (MCR) and decomposition rate (CR) according to the K value. Plasma radioimmunoassay was used to determine the hormone concentration.