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目的探讨1～6岁厌食症患儿血清瘦素及神经肽Y水平的变化及其相关性,分析其在厌食症发病过程中的作用。方法用放射免疫分析法检测47例厌食症患儿和35例正常小儿血清瘦素和神经肽Y水平,测量受试者身高和体质量,计算体质量指数(body mass index,BMI)。结果厌食症组患儿体内瘦素、神经肽Y和BMI显著低于正常对照组(P<0.05),3项检测指标之间无明显相关性(瘦素与神经肽Y和BMI分别为r=-0.12和r=0,05,P>0.05,神经肽Y与BMIr=0.18,P>0.05);正常对照组瘦素与BMI呈正相关(r=0.43,P<0.05)。结论瘦素与神经肽Y均在厌食症发病中起着重要作用,与厌食症发病机制有关,低瘦素水平可能是机体的一种防御反应,起到保护作用,神经肽Y可能是造成厌食症患儿食欲低下的重要因子。
Objective To investigate the changes and correlations of serum leptin and neuropeptide Y in children with anorexia after 1 ~ 6 years of age and analyze their roles in the pathogenesis of anorexia. Methods The levels of serum leptin and neuropeptide Y in 47 cases of anorexia and 35 normal children were detected by radioimmunoassay. The body mass and body mass index were measured. The body mass index (BMI) was calculated. Results The levels of leptin, neuropeptide Y and BMI in children with anorexia were significantly lower than those in normal control (P <0.05). There were no significant correlations between the three indexes (leptin, neuropeptide Y and BMI were r = -0.12 and r = 0,05, P> 0.05, neuropeptide Y and BMIr = 0.18, P> 0.05). There was a positive correlation between leptin and BMI in normal control group (r = 0.43, P <0.05). Conclusions Both leptin and neuropeptide Y play an important role in the pathogenesis of anorexia and are related to the pathogenesis of anorexia. Low leptin levels may be a defensive response to the body and play a protective role. Neuropeptide Y may be anorexia An important factor in children with poor appetite.