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采用问卷调查、致癌物质检测和致突变性研究等方法探讨了赞皇县胃癌高发区饮水与胃癌发生的可能关系。发现高发区居民饮用河水和饮用生水习惯者多 ;当地居民饮水中可检出苯并芘、亚硝胺、黄曲霉毒素B1、G1 的污染 ;赞皇县胃癌高发区和相对低发区饮水微量元素含量存在明显差别 ;赞皇县饮用水硝酸盐、亚硝酸盐含量显著高于河北省内胃癌低发区赤城(P<0.05) ;微核实验结果表明赞皇县胃癌高发区浓缩饮水水样具有致突变性 ,另外还可引起体外培养的人胚胃粘膜细胞增殖活性增强
By means of questionnaire, carcinogen detection and mutagenicity, the possible relationship between drinking water and gastric cancer in Zanhuang County is explored. Found that residents in high incidence areas drinking water and habit of drinking raw water were more; local residents drinking water can be detected benzopyrene, nitrosamines, aflatoxin B1, G1 pollution; Zanhuang County of high incidence of gastric cancer and relatively low drinking water Trace element content of Zanhuang County was significantly different; the content of nitrate and nitrite in drinking water in Zanhuang County was significantly higher than that in the low-incidence area of stomach cancer in Hebei Province (P <0.05); The result of micronucleus test showed that concentrated drinking water Like mutagenicity, in addition can also cause in vitro cultured human embryonic gastric mucosal cell proliferation activity increased