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本文对３６只冠脉临界狭窄的杂种犬施行了定量潘生丁负荷超声心动图试验（ＤＳＥＴ）。动物分为３组：小剂量（潘生丁０．５ｍｇ／ｋｇ／４ｍｉｎ，静注），大剂量组（潘生丁１．０ｍｇ／８ｍｉｎ，静注）。和对照组（生理盐水１０ｍｌ／４ｍｉｎ，静注用药前、后连续记示两维超声心动图（２ＤＥ），平均主动脉压（ＭＡＰ）、心率（ＨＲ）、左室舒张末期压（ＬＶＥＤＰ）、远端冠脉压（ＤＣＰ）和节段性冠脉阻力（ＳＣＲ），并同时观察ＥＣＧ。结果显示：大剂量潘生丁注射后，ＭＡＰ从１３．４±０．８下降到１０．６±１．０ｋＰａ（Ｐ＜０．０５）；ＨＲ略有减低（Ｐ＜０．０５），ＤＣＰ明显减少（下降３０～３５％），ＣＢＦ减少超过４０％，２ＤＥ可检出局部室壁运动异常（ＲＷＭＡ）；而在小剂量组，ＤＣＰ仅下降１０～２０％，ＣＢＦ增加１０～２０％，而ＨＲ无明显变化（Ｐ＞０．０５）。结论：冠脉临界狭窄时，由于ＣＢＦ和ＳＣＲ对定量潘生丁试验呈双向变化，所以，小剂量潘生丁不能诱发明显的ＲＷＭＡ，而大剂量潘生丁注射后，２ＤＥ即可检出明显的一过性心肌缺血。
Thirty-six dogs with critical stenosis were subjected to quantitative dipyridamole stress echocardiography (DSET). Animals were divided into 3 groups: low dose (dipyridamole 0.5mg / kg / 4min, intravenous injection), high dose group (dipyridamole 1.0mg / 8min, intravenous injection). (2DE), mean aortic pressure (MAP), heart rate (HR) and left ventricular end-diastolic pressure (LVEDP) were recorded before and after intravenous injection in the control group (normal saline 10ml / Distal coronary pressure (DCP) and segmental coronary resistance (SCR) were observed at the same time.The results showed that the MAP decreased from 13.4 ± 0.8 to 10.6 ± 1 after injection of large doses of dipyridamole. HR decreased slightly (P <0.05), DCP decreased significantly (decreased 30-35%), CBF decreased more than 40%, 2DE could detect regional wall motion abnormality (RWMA) (P> 0.05) .Conclusion: In the low-dose group, DCP decreased only 10-20% and CBF increased 10-20%, but there was no significant change in HR (P> 0.05) Test showed a two-way change, so small doses of dipyridamole can not induce significant RWMA, and high-dose pan After instillation, 2DE can detect significant transient myocardial ischemia.