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目的探讨缩宫素在剖宫产手术中不同给药方式对产妇循环功能的影响。方法研究1组于患者术中胎儿娩出后立即给予静脉注射缩宫素,剂量为10 U;研究2组患者推注方法、时间与1组相同,剂量改为20 U;对照组不予缩宫素注射。记录舒张压(DBP)、收缩压(SBP)、心率(HR)、血氧饱和度(SPO2)各时期变化值。结果对照组患者血压和心率始终处于稳定状态,各检测阶段比较差异无统计学意义(P>0.05);研究1组、2组患者于缩宫素注射后2 min血压明显下降、心率明显上升,与同时期对照组比较差异具有统计学意义(P<0.05),持续10 min后才逐渐恢复正常。三组患者各时期比较血氧饱和度差异无统计学意义(P>0.05)。研究1组、2组应用缩宫素产妇产后出血量明显低于对照组(P<0.05)。结论缩宫素在剖宫产术中对于产妇循环功能短期内具有极明显的影响,可降低血压、升高心率,但对血氧饱和度无影响。
Objective To investigate the effect of oxytocin on maternal circulatory function in different cesarean section operations. Methods A group of patients were given intrauterine injection of oxytocin immediately after their delivery. The dose was 10 U. The bolus injection method was the same in both groups. The dosage was changed to 20 U. The control group Injection. The changes of DBP, SBP, HR and SPO2 were recorded. Results The blood pressure and heart rate of patients in control group were always in steady state, and there was no significant difference in each testing stage (P> 0.05). In group 1 and group 2, the blood pressure decreased obviously and the heart rate increased obviously 2 minutes after oxytocin injection, Compared with the same period in the control group, the difference was statistically significant (P <0.05), continued to recover gradually after 10 min. There was no significant difference in the oxygen saturation between the three groups (P> 0.05). Study 1, 2 groups of oxytocin postpartum hemorrhage was significantly lower than the control group (P <0.05). Conclusions Oxytocin has a very significant effect on short-term maternal circulation in cesarean section, lowering blood pressure and increasing heart rate, but has no effect on oxygen saturation.