论文部分内容阅读
目的检测急性脑梗死患者血清对氧磷酶-1(paraoxonase 1,PON-1)和氧化型低密度脂蛋白(oxidized low density lipoprotein,ox-LDL)水平,分析急性脑梗死患者神经功能缺损与血清PON-1和ox-LDL水平的相关性。方法根据第四届全国脑血管病会议制订的诊断标准,选择符合条件的急性脑梗死患者78例、非脑梗死对照组52例。双抗体夹心ELISA法测定ox-LDL血清水平,采用乙酸苯酯法测定血清PON-1水平,所有急性脑梗死患者进行NIHSS评分和Glasgow昏迷评分。结果与非脑梗死对照组比较,脑梗死患者在性别、平均年龄和Glasgow昏迷评分上没有统计学意义,在危险因子上具有显著差别,脑梗死患者ox-LDL血清水平均显著高于对照组,PON-1血清水平均显著低于对照组。脑梗死患者NIHSS评分分数随着ox-LDL血清水平的增高而增加,随着PON-1血清水平的降低而增高。脑梗死患者Glasgow评分分数随着ox-LDL血清水平的增高而降低,随着PON-1血清水平的增高而增高。结论在急性脑梗死患者中血清PON-1和ox-LDL水平和神经功能缺损有着密切的关系。ox-LDL血清水平的越高,神经功能缺损就越重,相反PON-1血清水平的越低,神经功能缺损就越重。
Objective To detect the levels of paraoxonase-1 (PON-1) and oxidized low density lipoprotein (ox-LDL) in patients with acute cerebral infarction and to analyze the relationship between neurological impairment and serum Correlation of PON-1 and ox-LDL levels. Methods According to the diagnostic criteria of the Fourth National Conference on Cerebrovascular Disease, 78 patients with acute cerebral infarction and 52 non-cerebral infarction patients were selected. The serum level of ox-LDL was measured by double antibody sandwich ELISA. PON-1 level was measured by the phenyl acetate method. NIHSS score and Glasgow coma score were determined in all patients with acute cerebral infarction. Results Compared with non-cerebral infarction control group, there were no significant differences in gender, mean age and Glasgow coma score in patients with cerebral infarction, with significant differences in risk factors. The serum ox-LDL levels in patients with cerebral infarction were significantly higher than those in control group, PON-1 serum levels were significantly lower than the control group. The NIHSS score of patients with cerebral infarction increased with the increase of serum levels of ox-LDL and increased with the decrease of serum levels of PON-1. The Glasgow score of patients with cerebral infarction decreased with the increase of serum level of ox-LDL and increased with the increase of serum level of PON-1. Conclusion The levels of serum PON-1 and ox-LDL in patients with acute cerebral infarction have close relationship with neurological deficits. The higher the level of ox-LDL serum, the heavier the neurological deficit, whereas the lower the serum level of PON-1, the heavier the neurological deficit.