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所有造血细胞包括淋巴细胞,均来源于共同的干细胞。造血系统可分为三个主要的部分:第一部分最原始,由具有高度自我更新能力的造血干细胞(HSC)组成;第二部分由定向分化的祖细胞组成,它对体液调节因子起反应,并维持成熟血细胞的数量水平;第三部分由成熟的血细胞组成,已失去增殖能力。 1961年Till和McColloch首先发现脾结节法,对小鼠多能HSC提供定量的检测方法,以后又发展了半固体克隆细胞培养法以测定定向祖细胞,继后又建立了多能干细胞的克隆培养方法。一些研究者已报导了呈现三系以上的终末分化的体外造血集落,即粒细胞-红细胞-
All hematopoietic cells, including lymphocytes, are derived from common stem cells. The hematopoietic system can be divided into three main parts: the first part is the most primitive, consisting of highly self-renewing hematopoietic stem cells (HSCs); the second part consists of differentiated progenitor cells that respond to humoral regulatory factors and Maintain the level of mature blood cells; the third part of the mature blood cells, has lost the ability to proliferate. In 1961, Till and McColloch first discovered the spleen nodule method, which provided a quantitative test method for mouse pluripotent HSC. Later, it developed a semi-solid clonal cell culture method to measure the progenitor cells, and then established a clone of pluripotent stem cells Training methods. Some researchers have reported that in vitro hematopoietic colonies that present more than three lines of terminally differentiated, granulocyte-erythrocyte-