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目的:优选满山红总黄酮固体分散体的制备工艺。方法:分别以聚乙二醇6000(PEG6000),聚乙烯吡咯烷酮K30(PVPK30),泊洛沙姆188(Pluronic F68)为载体,采用适合载体的熔融-溶剂法和溶剂法制备满山红总黄酮-载体不同比例(1∶1,1∶2,1∶4,1∶6)的固体分散体。以满山红总黄酮为检测指标,通过UV测定体外溶出度,计算各固体分散体的T d值。结果:最佳制备工艺为以4倍量PVPK30为载体,加20倍量无水乙醇溶解,于50℃旋蒸除去无水乙醇,满山红总黄酮的体外溶出率达100%。PEG6000为载体时,不同比例的固体分散体T d分别为6.329,5.225,0.096,4.755 min;Pluronic F68为载体时,各固体分散体T d分别为4.045,3.561,0.018,0.026 min;PVPK30为载体时,各固体分散体T d分别为5.000,5.000,0.005,0.056 min。结论:溶剂法可用于制备满山红总黄酮固体分散体,具有很好的增溶效果,但不适合工业生产。
Objective: To optimize the preparation of Manshanhong total flavonoids solid dispersion. Methods: The total flavonoids of Manduca flavescens were prepared by melt-solvent method and solvent method using polyethylene glycol 6000 (PEG6000), polyvinylpyrrolidone K30 (PVPK30) and poloxamer 188 (Pluronic F68) - Solid dispersions of different ratios of carriers (1: 1, 1: 2, 1: 4, 1: 6) Taking the total flavonoids of Mangosteen as test index, the in vitro dissolution rate was measured by UV, and the T d value of each solid dispersion was calculated. Results: The optimum preparation process was as follows: 4 times PVPK30 as carrier, 20 times ethanol and 20% ethanol, and then desalted at 50 ℃ to remove absolute ethanol. The dissolution rate of total flavonoids was 100%. PEG6000 as carrier, the T d of solid dispersions with different ratios were 6.329, 5.225, 0.096, 4.755 min, respectively. When Pluronic F68 was used as carrier, the T d of each solid dispersion was 4.045, 3.561, 0.018 and 0.026 min, respectively. PVPK30 was the carrier , The respective solid dispersions Td were 5.000, 5.000, 0.005, 0.056 min, respectively. Conclusion: The solvent method can be used to prepare the solid dispersion of total flavonoids of mangosteen, has a good solubilization effect, but not suitable for industrial production.