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采用光照核黄素（LRF）产生氧自由基（OFR），观察后者在外周和脊髓水平对疼痛的影响．发现在外周，小鼠足跖部皮下注射（ipl）LRF0.067，0.67mmol.mouse-1有致痛作用，脊髓水平，小鼠鞘内注射LRF0．106～0，665nmol.mouse－1有致痛每作用;进一步研究发现OFR的脊髓痛敏与Ca2+有④切关系，用维拉帕米、尼莫地平、EGTA可拮抗OFR的痛敏作用．并证明阿斯匹林、吲哚美辛的镇痛作用与清除OFR有关．
Radionuclide riboflavin (LRF) was used to generate oxygen free radicals (OFR), and the effect of the latter on peripheral and spinal cord pain was observed. Found in the peripheral, mouse foot plantar subcutaneous injection (ipl) LRF0.067,0.67mmol.mouse-1 have a pain effect, spinal cord levels, mouse intrathecal injection of LRF0.106 ~ 0,665nmol.mouse-1 have pain caused by each Further study found that OFR spinal pain and Ca2 + have cut relationship, with verapamil, nimodipine, EGTA can antagonize the pain of the OFR. And proved aspirin, indomethacin analgesic effect and the removal of OFR.