论文部分内容阅读
一氧化碳(carbon monoxide,CO)这种双原子气体,近年来被证实对于体内某些病理情况有着细胞保护作用或诊断价值,其体内主要来源于血红素裂解产物。诸如体内肺损伤所致炎症,CO可减少炎症因子产生从而抗炎;体内细胞凋亡,CO可通过抑制活性氧而阻止细胞死亡;此外,可通过降低炎症因子而对缺血再灌注有保护作用,从而可用于保护器官移植;还可通过测定CO浓度而体现危重病严重度,从而用于重症监护室危重病的监测;基于这些作用,CO对一系列疾病有治疗或诊断作用。现针对其细胞保护作用及其在临床中的应用若干进展作一综述。
Carbon monoxide (CO), a diatomic gas, has been shown to have cytoprotective or diagnostic value for some pathological conditions in vivo in recent years, and its body mainly comes from heme pyrolysis products. Such as inflammation caused by lung injury in the body, CO can reduce the production of inflammatory cytokines and thereby prevent inflammation; in vivo apoptosis, CO can prevent cell death by inhibiting reactive oxygen species; furthermore, it can protect ischemia-reperfusion by reducing inflammatory cytokines , Which can be used to protect the organ transplant; CO concentration can also be measured by the severity of critical illness, which was used for critical care intensive care monitoring; based on these effects, CO treatment or diagnosis of a series of diseases. Now its cytoprotection and its clinical application of a number of progress made.