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粘膜与皮肤的淋巴结综合症(MLNS)最初描述于1967年,1973年报导在日本患该病的在7000人以上。据观察自1972年以来该病在美国的发病率渐趋增加。一例12岁的白种人女孩表现为于胸肿和硬化了的红斑性疹子呈长袜——手套样分布于于和脚上。发烧、咽喉炎、口唇干燥皲裂、双侧结膜充血、全身不适以及在斑丘疹遍及肢端的第二天出现杨梅舌。发热持续5天伴有头痛、肌肉痛、全身不适和极小的颈淋巴腺肿。实验室检查显示血沉30、白血球13,000、肝功能轻度损害,咽培养阴性,抗“○”及病毒、立克次氏体属之滴定度为阴性。发病后第七天与长袜—手套样分布的疹区相同之部位开始皮肤脱屑。
Mucosal and cutaneous lymph node syndrome (MLNS) was first described in 1967, and in 1973 it was reported that it was above 7,000 in Japan. It is observed that the incidence of the disease in the United States has gradually increased since 1972. A 12-year-old Caucasian girl showed stockings on a swollen and hardened erythema rash - a glove-like pattern spread over her feet. Fever, sore throat, dry chapped lips, bilateral conjunctival hyperemia, general malaise, and bayberry tongue appeared the day after the rash appeared throughout the extremities. Fever for 5 days accompanied by headache, muscle pain, general malaise and minimal cervical lymph gland swelling. Laboratory tests showed erythrocyte sedimentation rate 30, leukocyte 13,000, mild damage to liver function, negative pharyngeal culture, resistance to “o” and virus, and titration of rickettsia was negative. The seventh day after onset and stockings - glove-like distribution of rash area the same part of the skin scaling began.