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目的调查大同市妊娠期女性人乳头瘤病毒(HPV)感染及亚型分布情况。方法采用PCR以及线形杂交法(LA)对177例妊娠期女性宫颈脱落细胞标本进行HPV检测和基因分型。结果大同市妊娠期女性HPV感染率为38.42%,妊娠早期感染率最高(57.35%,P﹤0.005),且以多型别为主(73.92%)。HPV-16、HPV-58、HPV-18、HPV-11以及HPV-6的感染率最高,分别为15.82%,4.52%,3.95%,3.95%和3.39%。结论大同市妊娠期女性HPV的感染较为普遍,HPV亚型分布具有明显的地域特征,妊娠早期女性为易感人群。
Objective To investigate the prevalence and subtype distribution of human papillomavirus (HPV) in pregnant women in Datong City. Methods 177 cases of cervical exfoliated cells from pregnant women were genotyped by PCR and linear hybridization (LA). Results The prevalence of HPV infection in pregnant women in Datong was 38.42%. The highest infection rate in early pregnancy was 57.35% (P <0.005), and the majority of them were typed (73.92%). The highest infection rates of HPV-16, HPV-58, HPV-18, HPV-11 and HPV-6 were 15.82%, 4.52%, 3.95%, 3.95% and 3.39%, respectively. Conclusion The prevalence of HPV infection in pregnant women in Datong City is more common. The distribution of HPV subtypes has obvious regional characteristics. Women in early pregnancy are predominant susceptible people.