论文部分内容阅读
应用免疫组化SP法对94例乳腺癌、41例乳腺良性病变和10例正常乳腺组织进行了细胞粘附分子CD_(15)检测。结果发现,CD_(15)。在乳腺癌和乳腺良性病变的阳性率分别为79.8％和58.3％,两者有显著差异性(P<0 01),10例正常乳腺组织仅4例呈CD_(15)弱阳性反应。CD_(15)表达与患者年龄和肿瘤大小无显著关系。CD_(15)表达阳性率在浸润性导管癌中显著高于单纯癌(P<0.05),组织学Ⅱ～Ⅲ级显著高于Ⅰ级者(P<0.05),临床Ⅲ一Ⅳ期显著高于Ⅰ期和Ⅱ期者(P<0.05),淋巴结转移阳性组显著高于阴性组(P<0.01)。在一组原发部位和淋巴结转移性乳腺癌配对标本中,CD_(15)表达无明显差异性。CD_(15)阳性的乳腺癌Cath-D和c-erbB-2的表达阳性率均显著高于CD_(15)阴性者(P<0.001)。结果提示,CD_(15)的表达与乳腺癌的发生发展、浸润转移及预后有密切关系。
Immunohistochemical SP method was used to detect the cell adhesion molecule CD_(15) in 94 cases of breast cancer, 41 cases of benign breast lesions and 10 cases of normal breast tissues. As a result, CD_(15) was found. The positive rates of breast cancer and benign breast lesions were 79.8% and 58.3%, respectively. There was a significant difference between the two (P<0.01). Only 10 cases of normal breast tissue showed CD_(15) weak positive reaction. CD_(15) expression had no significant relationship with patient age and tumor size. The positive rate of CD_(15) expression was significantly higher in infiltrating ductal carcinoma than in simple carcinoma (P<0.05). The histological grades II~III were significantly higher than grade I (P<0.05). In stage I and stage II (P<0.05), lymph node metastasis was significantly higher in the positive group than in the negative group (P<0.01). In a pair of primary site and lymph node metastatic breast cancer matched specimens, there was no significant difference in the expression of CD_(15). The positive rates of Cath-D and c-erbB-2 expression in CD15-positive breast cancer were significantly higher than those in CD15-negative patients (P<0.001). The results suggest that the expression of CD_(15) is closely related to the occurrence, development, infiltration, metastasis and prognosis of breast cancer.