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Tongluo Huatan capsule(通络化痰胶囊)improves cognitive func-tion by regulating the endocytosis of N-methyl
OBJECTIVE:To explore the neuroprotective mecha-nisms of Tongluo Huatan capsule (THC) in a rat model of vascular dementia......
Dying by fire: noncanonical functions of autophagy proteins in neuroinflammation and neurodegenerati
Neuroinflammation and neurodegeneration are key components in the establishment and progression of neurodegenerative dis......
In this study,we investigated the in vivo behaviors of chiral cobalt oxide nanoparticles (Co3O4 NPs) stabilized with D-o......
A key challenge to strengthen the anti-tumor efficacy was to maximize the nano-drug ingestion to tumor cells through siz......
Many viruses infect host cells utilizing receptor-mediated endocytosis, but part of their machineries remain unrevealed.......
Combating Drug Resistance in hepatocellular carcinoma cells through inhibition of ABC family protein
Multidrug resistance is an unavoidable obstacle in the development of anticancer research.Platinum(Pt)based complexes ha......
Cellular uptake enhancement and internalization pathways determination for intracellular polymeric p
Successful controlled release for intracellular delivery requires both sufficient cellular uptake and suitable internali......
Entry of Bombyx mori nucleopolyhedroviruse (BmNPV) into BmN Cells by cholesterol-dependent macropino
BmNPV is a serious viral pathogen of silkworm,and no drug or specific protection is available at present time.Although m......
Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulati
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Activity-dependent BDNF release via endocytic pathways is regulated by synaptotagmin-6 and complexin
Brain-derived neurotrophic factor(BDNF)is known to modulate synapse development and plasticity,but the source of synapti......
Endoplasmic reticulum stress contributes to acetylcholine receptor degradation by promoting endocyto
INTRODUCTION AND OBJECTIVES After binding by acetylcholine released from a motor neuron, a nicotinic acetylcholine recep......
Guidance cues are critical for axon navigation and ultimately for the wiring of the neuro-circuits during nervous system......
Brain-derived neurotrophic factor (BDNF) is known to be crucial for synaptic development and plasticity in the central n......
Unraveling a molecular determinant for clathrin-independent internalization and subsequent degradati
Endocytosis and postendocytic sorting of G-protein-coupled receptors (GPCRs) is of obvious importance for regulation of ......
Growth cones of growing axons can sense both attractive and repulsive cues in the environment and make a corresponding r......
Synaptic vesicle exocytosis-based neurotransmission and the subsequent membrane retrieval through endocytosis are crucia......
Cellular uptake mechanism, intracellular fate and exocytosis of polyamidoamine dendrimers in MCF-7 c
PAMAM dendrimers have been attracting more attention for delivering drugs and genetic materials to resistant cells.Howev......
Five mammalian members of the CLC family of chloride channels and transporters,C1C-3 through ClC-7, are predominantly ex......
Paradoxical relationship between RAVE (relative activity versus endocytosis) values of several opioi
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It has been observed that rare earth elements(REEs)regulate multiple aspects of plant growth and development since 1917.......
The widespread application of rare earth elements(REEs)have caused the accumulation of REEs in the environment....
Endocytosis is essential to all eukaryotes,but how cargoes are selected for internalization remains poorly characterized......
回音壁模式是光子在一个准二维平面内运动,并不断地在微腔边界发生全反射而不折射出腔的一种光学模式,具有高的Q值和小的模式体积,......
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Distinct Rab7-related Endosomal–Autophagic–Lysosomal Dysregulation Observed in Cortex and Hippocampu
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Liposomes, especially cationic liposomes, are the most common and well-investigated nanocarriers for biomedical applicat......
The plant plasma membrane (PM) is highly dynamic and PM proteins play important roles in regulating various transpor......
Differential regulation of clathrin and its adaptor proteins, AP-2 and the TPLATE complex, during th
In plants,clathrin-mediated endocytosis (CME) is dependent on the function of clathrin and its accessory heterooligo......
Endocytosis in S. cerevisiae was mainly regulated by two Rab modules (Vps21 and Ypt7 modules, respectively, each con......
RNA interference(RNAi)is highly efficient and sequence-specific degradation of endougenous genes,which is conserved ......
Tissue mechanics provides an appropriate niche for cell growth and functions.Integrin proteins play a pivotal role i......
Preparation and Characterization of Teniposide PLGA Nanoparticles and Their Uptake in Human Glioblas
Many studies have demonstrated the uptake mechanisms of various nanoparticle delivery systems with different physico......
据报道,酵母中HOPS复合体参与囊泡融合及运输。本研究分别以酿酒酵母HOPS复合体各亚基氨基酸序列,通过BLASTp在稻瘟病菌数据库中搜......
The binding of recombinant human macrophage colony-stimulating factor (M-CSF) soluble receptor (rh-M-CSF-sR) to membrane......
生物膜的磷脂双分子层将细胞与外界环境分开。大部分细胞会在机械损伤或化学应激下引发质膜损伤,如果不及时修复将会导致细胞死亡......
Secretory pore-forming proteins(PFPs)have been identified in organisms from all kingdoms of life.Our studies with the to......
Effects of TAM-derived exosomes on migration and invasion of MDA-MB-231 cells in triple negative bre
Objective: To investigate the effects of exosomes derived from tumor-associated macrophages (TAMs) on migration and inva......
Effects of TAM-derived exosomes on migration and invasion of MDA-MB- 231 cells in triple negative br
Objective:To investigate the effects of exosomes derived from tumor-associated macrophages(TAMs)on migration and invasio......
Impact of molecular weight on the mechanism of cellular uptake of polyethylene glycols (PEGs) with p
Polyethylene glycols (PEGs) in general use are polydisperse molecules with molecular weight (MW) distributed around an a......
据报道,酵母中HOPS复合体参与囊泡融合及运输.本研究分别以酿酒酵母HOPS复合体各亚基氨基酸序列,通过BLASTp在稻瘟病菌数据库中搜......
当今聚合技术的发展为合成各种非线形两亲性聚合物提供了手段,对于包载模型药物的杂臂聚合物胶束的摄取和跨膜转运却鲜有报道.本文......
靶向肿瘤细胞的药物研发近年来受到了极大的关注,除了阻断细胞信号通路的蛋白激酶抑制剂外,叶酸受体介导的药物释放也引起了研究者......
,IL-12 suppression, enhanced endocytosis and up-regulation of MHC-Ⅱ and CD80 in dendritic cells duri
Aim: The aim of this study was to investigate endocytosis, MHC-Ⅱ expression and co-stimulatory molecule expression, as ......
Nicotinic acetylcholine receptors (nAChRs) play critical roles throughout the body. Precise regulation of the cellular l......
