Objective This study is to illustrate the effects of CXCL12 on GABA and ACh secretion and its mechanisms.Methods Primary......

As a kind of functional water-soluble fullerene derivative,fullerenol has driven extensive applications in biomedical fi......

OBJECTIVE Cranial radiotherapy is clinically used in the treatment of brain tumors;however,the consequent cognitive and ......

Gamma-amino-butyric acid(GABA)-containing interneurons are crucial to both development and function of the brain. Down-r......

Monocarboxylate transporters(MCTs), which carry monocarboxylates such as lactate across biological membranes, have been ......

Post-ischemic long-term potentiation(i-LTP) is a pathological form of plasticity that was observed in glutamate receptor......

Our previous study showed that when glutamate receptor(Glu R)6 C terminus-containing peptide conjugated with the human i......

Environmental enrichment attenuates hippocampal synaptic injury induced by prenatal stress in offspring. However, the in......

The effect of monosialoganglioside GM1 of different doses on the long-term potentiation (LTP) of synaptic transmission h......

This study investigated the effects of progesterone(P4) on the production and survival of neurons in the hippocampal den......

A two-photon fluorescent probe TPZn was developed for specific ratiometric imaging Zn2+in living cells and tissues. Sign......

BACKGROUND: The pharmacological action of opioid drugs is related to signal transduction of inhibitory guanine nucleotid......

Objective The effect of the ephedra/ephedrine alkaloid methylephedrine(dl-methylephedrine hydrochloride for testing in t......

Fructose-1,6-diphosphate is a metabolic intermediate that promotes cell metabolism. We hypothesize that fructose-1,6-dip......

Based on the lead compounds 1 and 2, a series of novel BACE1 inhibitors were designed and synthesized,among which compou......

c-Jun NH2-terminal kinase(JNK)-interacting protein 3 plays an important role in brain-derived neurotrophic factor/tropom......

BACKGROUD: Ethanol can influence neural development and the ability of learning and memory, but its mechanism of the neu......

Objective:To study effects of behavior training on learning,memory and the expression of NR2B,GluR1 in hippocampus of ra......

Aim:To evaluate the effects of global system for mobile communications (GSM)1800 MHz microwaves on dendritic filopodia,......

OBJECTIVE Ketamine is an injectable anesthetic and recreational drug of abuse commonly used worldwide. Many experimental......

Chronic cerebral ischemia is a pathological process in many cerebrovascular diseases and it is induced by long-term hype......

In the present study, a rat model of type 2 diabetes mellitus was established by continuous peritoneal injection of stre......

Carboxypeptidase E(CPE) is a prohormone-processing enzyme and sorting receptor that functions intracellularly.However, r......

N-methyl-D-aspartate receptors(NMDARs) containing different GluN2 subunits play distinct roles in synaptic plasticity.Su......

MicroRNA alterations have been reported in patients with Alzheimer ’s disease(AD) and AD mouse models. We now report th......

Activation of extracellular signal-regulated kinase 1/2 has been demonstrated in acute brain ischemia. We hypothesized t......

In this study, we investigated the effects of streptozotocin-induced type 1 diabetes on antioxidant-like protein-1 immun......

BACKGROUND: 3, 4-methylenedioxymethamphetamine (MDMA, also known as “ecstasy”) hasbeen shown to exhibit neurotoxic ef......

Anisodine(AT_3)is a new alkaloid isolatedfrom Scopolia tangutica,Anisodus tanguticus,a plant of Solauaeeae family,colle......

目的 观测逍遥散对慢性应激损伤大鼠海马对下丘脑-垂体-肾上腺(HPA)轴调控的变化,探讨逍遥散抗应激损伤的神经内分泌变化.方法 以......

In adult mammals, axon regeneration after central nervous system injury is very poor, resulting in persistent functional......

目的探讨磁共振波谱（MRS)对原发性癫痫患者海马病变的术前定位诊断价值。方法对50例原发性癫痫患者（癫痫组）和32例健康志愿者（健康对照......

目的探讨生长激素释放肽（Ghrelin）对全脑缺血/再灌注（I/R）大鼠海马神经元的保护效应及其作用机制。方法按随机数字表法将雄性SD大鼠分......

BACKGROUND: It has been found in recent years that STAT3 widely distributes in nervous system, including hippocampal CA1......

Background The existence of neurogenesis in the hippocampus of adult nonhuman primates has been confirmed in recent year......

Lambda-cyhalothrin(LCT),one of the type II pyrethroids,has been widely used throughout the world.The estrogenic effect o......

BACKGROUND: The decrease of mitochondrial membrane potential (MMP) is an irreversible marker of neuronal apoptosis durin......

BACKGROUND: Some scholars believed that the neuronal injury after status epilepticus is apoptosis, the main evidence is ......

BACKGROUND: At present, researches on differentiating from human adipose-derived adult stromal cells (hADASC) to neuron-......

BACKGROUND: Phycocyanin can anti-oxidize and clear free radial. Whether its protective effect on brain is related to Cas......

BACKGROUND: It has been demonstrated that histamine and its receptors in the hippocampus play an important role in memor......

研究钙内流对原代培养的皮质和海马神经元内ｐＨ（ｐＨｉ）的影响。为了达到此目的，暴露单个神经元于谷氨酸（Ｇｌｕ，１００μｍｏｌ／Ｌ）或氯化钾（ＫＣｌ，５０ｍｍｏｌ／Ｌ）。用微荧光法测定细胞内游离......

Interleuldn-6 (IL-6) has been shown to have several effects on the nervous system.In the present study, we examined the......

HU Guo-Yttan, ZHANG Jing-Ming(State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Acad......

Being the functional basis of neural networks, neuronal signal integration has been currently becoming a hot point of n......

Objective To detect for hippocampal sclerosis presurgically in a group of patients with refractory temporal lobe epilep......

从40年前第一次提出成年脑内有神经元再生,直到今天人们才真正意识到和接受这个事实。这要归功于近15年的神经工作者辛勤研究和科......

LTP(长时程动作电位增强,或称长时程增强)是目前神经科学热点课题。各方面研究支持LTP与学习及记忆过程相关。基于其发生机制,LTP......

脑、神经元、神经突触都具有可塑性。脑发育过程中其可塑性最强,成年脑仍具有可塑性。对神经可塑性的研究,大致可分类为发育可塑性......

AIM: To study the blockade of paeoniflorin (Pae) on I_(Na) in the acutely isolated hippocampus neurons of mice. METHODS......