ubiquitination相关论文
Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mi
Parkin,an E3 ubiquitin ligase,plays a role in maintaining mitochondrial homeostasis through targeting damaged mitochondr......
Objective: Hepatitis B virus (HBV) infection is a major public health problem worldwide. However, the regulatory mechani......
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Arabidopsis F-BOX STRESS INDUCED 4 is required to repress excessive divisions in stomatal developmen
During the terminal stage of stomatal development,the R2R3-MYB transcription factors FOUR LIPS(FLP/MYB124) and MYB88 lim......
[目的]微孢子虫是一类专性细胞内寄生的真核病原微生物,能够感染人类和几乎所有的动物.本课题以海伦脑炎微孢子虫(Encephalitozoon......
Cyclophilin A (CypA) is a peptidyl-prolyl cis/trans isomerase that interacts with the matrix protein (M1) of influenza A......
BTB protein MdBT2 inhibits anthocyanin and proanthocyanidin biosynthesis by triggering MdMYB9 degrad
MdMYB9 is a positive regulator for the biosynthesis of anthocyanin and proanthocyanidin in apple.However, it is unclear ......
The E3 ubiquitin ligase CHIP mediates ubiquitination and proteasomal degradation of PRMT5 during ost
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USP13 knockdown inhibits gastric cancer cell epithelialmesenchymal transition,invasion and metastasi
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The E3 ligase RNF185 negatively regulates osteogenic differentiation by targeting Dvl2 for degradati
Osteoblast plays a pivotal role in bone metabolism and bone remodeling by mediating bone formation and regulating the ac......
HERC3-mediated SMAD7 ubiquitination degradation promotes autophagy-induced EMT and chemoresistance i
Objective Glioblastoma(GBM)is the most common malignant intracranial tumor with themost dismal prognosis.New evidence su......
Objective A number of guanine nucleotide exchange factors(GEFs)including cell transforming factor ECT2 are believed to d......
Regulatory mechanism of glutamate transporters expression by ubiquitin ligase E3 Nedd4-2 in Parkinso
Objective To study the molecular mechanism of abnormal glutamate transporter expression and function in Parkinsons disea......
To define the factors responsible for ischemia-induced blood-brain barrier damage is first necessary before a new strate......
Epigenetic regulation of IL-12/IL-23 gene expression and autoimmune responses by deubiquitinase Trab
Aims: The proinflammatory cytokines IL-12 and IL-23 connect innate immunity to adaptive immune responses and are also in......
Ubiquitin E3 ligase SPOP regulates the stability of histone H3K36 methyltransferase SETD2 and DNA da
Trimethylation of histone H3K36 is a chromatin mark associated with active gene expression, which has been implicated in......
The γ-secretase blocker reduces the permeability of the blood-brain barrier by decreasing the ubiqui
Aim: Cerebral ischemia/reperfusion injury induces alterations in many signaling pathways that underlie BBB disruption an......
Sublytic C5b-9 promotes proliferation of glomerular mesangial cells in rat Thy-1 nephritis through T
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Genetic studies in various animal models indicate that Piwi genes are crucial to animal germline development.However, wh......
Posttranslational modification of proteins by ubiquitin (Ub) plays an important role in diverse cellular events,includin......
Ubiquitin and ubiquitin-like conjugation is one of the most important post-translational modifications responsible for r......
Interleukin-10 (IL-10) initiates potent anti-inflammatory effects via activating its cell surface receptor, composed of ......
Ubiquitination is an important and reversible post-translational modification that regulates the stability,localization ......
The HECT type E3 ligases are key regulators of cell growth and proliferation,and malfunctions of these enzymes are assoc......
VHL negatively regulates SARS-CoV replication by interacting with nsp16 and promoting its instabilit
Most eukaryotic cellular and some viral mRNAs contain functional modified 5terminal "cap" structure.SARS coronavirus(S......
K63-linked TAK1 Polyubiquitination at Lys-158 Residue is Required for TNFα and IL-1 β-induced IKK/NF
TAK1 plays an easential role in proinflammatory cytokine TNFα and IL-1β-induced IKK/NF-κB and JNK/AP-1 activation.Her......
RHOBTB3 promotes proteasomal degradation of HIFα through facilitating hydroxylation and suppresses t
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Cell-surface localization of Pellino antagonizes Toll-mediated innate immune signalling by controlli
Innate immunity mediated by Toll signalling has been extensively studied, but how Toll signalling is precisely controlle......
Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitin-dependent proteosomal deg
Severe acute respiratory syndrome coronavirus(SARS-CoV)encodes eight accessory proteins,the functions of which are not y......
Background: The existence and function of most proteins in the human proteome are regulated by the ubiquitination proces......
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Aims: The Maf family proteins belong to the basic leucine zipper transcription factors,including c-fos andc-jun.The tran......
DNAH2 facilitates the homologous recombination repair of Fanconi anemia pathway through modulating F
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目的观察弥漫大B细胞淋巴瘤（DLBCL）患者小泛素相关修饰蛋白特异性蛋白酶（SENP）1和小泛素相关修饰蛋白（SUMO）1的表达水平，分析其评估预后的......
Centromeres are chromosomal loci marked by histone variant CenH3 (centromeric histone H3) and essential for genomic stab......
Interferon regulatory factors (IRFs) play pivotal and critical roles in innate and adaptive immune responses;thus,precis......
Allergic asthma that is caused by inhalation of house dust mites(HDMs)is mainly mediated by Th2 cells.Recently,the roles......
Suppression of HIV-1 Integration by Targeting HIV-1 Integrase for Degradation with A Chimeric Ubiqui
Human immunodeficiency virus(HIV) attacks human immune system and causes life-threatening acquired immune deficiency syn......
RNF220-mediated K63-linked ubiquitination and sequestration shapes the Gli gradient required for ven
In mammals,different groups of neurons are generated in the ventral neural tube along the dorsal-ventral axis,includ......
Mareks disease (MD) is a highly contagious lymphoproliferative diseases of chickens caused by Mareks disease virus (......
HAF1 mediates circadian accumulation of OsELF3 in determining the heading date of rice under long-da
Plant circadian clock has been provided to be involved in multiple physiology and metabolism process by monitoring e......
Barley NLR Receptor Triggers Immunity by Derepressing Defense Transcriptions through Acetylation and
Plant employs NLR receptors to recognize isolate-specific effectors and induce massive transcriptional reprogramming......
C-terminus of Hsc70 interacting protein(CHIP)inhibits myocardin transactivation through ubiquitin-me
Myocardin is a smooth and cardiac muscle-specific transcriptional coactivator of serum response factor, and plays an......
Two distinct ubiquitin ligases, Mdm2 and c-Cb(l), have different functions in regulation of the IGF-
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Tomato nuclear proteome reveals the involvement of specific E2 ubiquitin-conjugating enzymes in frui
Fruits are unique to flowering plants and play a central role in seed maturation and dispersal.Molecular dissection ......
Higher plants deploy a large repertoire of Pattern-Recognition Receptors (PRRs),composed of Receptor Kinases (RKs) o......
泛素化系统调节真核细胞中几乎所有的生命活动,参与细胞内绝大多数蛋白质的降解,而疾病的发生往往伴随着相关蛋白质的异常。研究与......
Recent advances in the chemical synthesis and semi-synthesis of poly-ubiquitin-based proteins and pr
Ubiquitination, a key and extensive posttranslational modification of proteins, has profound effects on a variety of phy......
目的 检测前列腺癌PC3细胞中泛素连接酶NEDD4-1 (neural precursor cell expressed developmentally downregulated 4-1,NEDD4-1)......
目的 探讨FBXO22基因在乳腺癌血管形成中的作用及分子生物学机制.方法 使用FBXO22-SiRNA转染人乳腺癌MDA-MB-231和BT-549细胞,体外......
