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[目的]观察天麻藤玉丸联合贝那普利治疗高血压早期肾损害(阴虚阳亢)疗效。[方法]使用随机平行对照方法,将120例住院及门诊患者按就诊顺序编号随机分为两组。对照组60例贝那普利10mg/次,1次/d。治疗组60例天麻藤玉丸(天麻、生地、钩藤、玉米须、徐长卿、川牛膝;院内制剂),9g/次,2次/d;贝那普利治疗同对照组。连续治疗12周为1疗程。观测临床症状、血压、证候积分、肾功能指标、不良反应。治疗1疗程,判定疗效。[结果]降压疗效、证候疗效治疗组疗效优于对照组(P<0.01)。SBP、DBP、眩晕、头痛、腰膝酸软、五心烦热、心悸、耳鸣、总分、血Cys C、血β2-MG、尿mAlb治疗组优于对照组(P<0.05)。[结论]天麻藤玉丸联合贝那普利治疗高血压早期肾损害(阴虚阳亢),疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of Tianma Toutuyu pills combined with benazepril in the treatment of early renal damage of hypertension (yang and yang hyperactivity). [Methods] Using randomized parallel control method, 120 inpatients and outpatients were randomly divided into two groups according to the order numbers. The control group, 60 benazepril 10mg / time, 1 time / d. Treatment group, 60 cases of Tianma Fujuyu pills (Gastrodia elata, habitat, Uncaria, corn, Xu Changqing, Achyranthes; hospital preparations), 9g / time, 2 times / d; benazepril treatment with the control group. Continuous treatment for 12 weeks for a course of treatment. Observation of clinical symptoms, blood pressure, syndrome score, renal function indicators, adverse reactions. Treatment of a course of treatment to determine the efficacy. [Results] The curative effect of antihypertensive effect and syndrome treatment group was better than that of control group (P <0.01). SBP, DBP, dizziness, headache, weak knee, five upset, heart palpitations, tinnitus, total score, serum Cys C, blood β2-MG and urine mAlb in the treatment group were better than those in the control group (P <0.05). [Conclusion] Tianma Fujuyu pills combined with benazepril in the treatment of early hypertensive renal damage (Yin Yang Yang Kang), with satisfactory results, no serious adverse reactions, it is worth promoting.