采用复合终点作为随机临床试验的主要结局指标有时会掩盖各个终点事件间的巨大差别,在临床实践中如何参照这些临床试验的结果呢?由于医学在过去20年中的进步,继发于常见病(如心肌梗死)的不良事件发生率降低了。这一点对患者是有益的,但对临床研究者来说,低事件发生率却带来更大 The use of composite endpoints as the primary outcome measure for randomized clinical trials sometimes masks the vast differences between endpoints and how these clinical trials are referred to in clinical practice? Because of advances in medicine over the past two decades, secondary to common diseases (Such as myocardial infarction) the incidence of adverse events decreased. This is good for patients, but for clinical researchers, the incidence of low events leads to greater